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Entecavir Hydrate

Catalog No.
A1767
Antiviral drug used in hepatitis B infection
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$72.00
In stock
5mg
$66.00
In stock
25mg
$187.00
In stock
100mg
$330.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Entecavir hydrate is a reverse transcriptase inhibitor.
Reverse transcriptase (RT) is used to generate complementary DNA (cDNA) from an RNA template, which is mainly associated with retroviruses, such as HBV.
Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. In 17 patients with hepatitis B virus (HBV) genotype C, treatment with peginterferon
(PEG-IFN) a-2b combination with entecavir hydrate (ETV) for 48 weeks. Among 11 patients exhibited pretherapy HBeAg, 8 showed HBeAg seroconversion. Serum HBV DNA levels reduced by 5.2 and 3.3 log copies/ml by the end of the therapy and follow-up periods, respectively. Intrahepatic cccDNA reduced to 1.4 log copies/mg.  
References:
[1]. Hagiwara S, Kudo M, Osaki Y, et al. Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B. J Med Virol, 2013, 85(6): 987-995.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt295.29
Cas No.209216-23-9
FormulaC12H15N5O3·H2O
Solubilityinsoluble in EtOH; insoluble in H2O; ≥9.7 mg/mL in DMSO
Chemical Name2-amino-9-[(3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one;hydrate
SDFDownload SDF
Canonical SMILESC=C1C(CC(C1CO)O)N2C=NC3=C2NC(=NC3=O)N.O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control