SNC 80
SNC 80 is a highly selective and potent nonpeptide agonist of the δ-opioid receptor, with an IC50 value of 2.73 nM. The δ-opioid receptor, most heavily expressed in the basal ganglia and neocortical regions of the brain in human, participates not solely in the control of pain but also of mood disorders such as anxiety and depression. Selective δ-opioid receptor agonists may serve as potential therapeutic agents for chronic pain with ancillary anxiolytic- and antidepressant-like effects. Moreover, compared to μ-opioid receptor agonists, molecules acting on δ-opioid receptors typically show reduced adverse effects.?
References:
1.?Calderon SN, Rothman RB, Porreca F, et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. Journal of Medicinal Chemistry, 1994, 37(14): 2125-2128.
2.?Quirion B, Bergeron F, Blais V, et al. The Delta-Opioid Receptor; a Target for the Treatment of Pain. Frontiers in Molecular Neuroscience, 2020, 13: 52.
3.?Bilsky EJ, Calderon SN, Wang T, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. Journal of Pharmacology and Experimental Therapeutics, 1995, 273(1): 359-366.
| Physical Appearance | A white to off- |
| Storage | Store at RT |
| M.Wt | 449.64 |
| Cas No. | 156727-74-1 |
| Formula | C28H39N3O2 |
| Solubility | Soluble in DMSO |
| Chemical Name | 4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=CC=C(C=C1)[C@H](C2=CC=CC(OC)=C2)N3[C@@H](C)CN(CC=C)[C@H](C)C3)N(CC)CC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[3] | |
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Cell lines |
Mouse vas deferens |
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Reaction Conditions |
2.73 nM SNC 80 |
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Applications |
SNC 80 was potent in producing inhibition of electrically induced contractions of mouse vas deferens, but not in inhibiting contractions of the guinea pig isolated ileum (IC50 values of 2.73 and 5457 nM, respectively). |
| Animal experiment:[3] | |
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Animal models |
Mice |
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Dosage form |
104.9 nmol, 69 nmol, and 57 mg/kg Intracerebroventricular (i.c.v), intrathecal (i.th.) and intraperitoneal (i.p.) administration |
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Applications |
SNC 80 produced dose- and time-related antinociception in the mouse warm-water tail-flick test after i.c.v., i.th. and i.p. administration. The calculated A50 values (and 95% C.I.) for SNC 80 administered i.c.v., i.th. and i.p. were 104.9 (63.7-172.7) nmol, 69 (51.8-92.1) nmol and 57 (44.5-73.1) mg/kg, respectively. The i.c.v. administration of SNC 80 also produced dose- and time-related antinociception in the hot-plate test, with a calculated A50 value (and 95% C.I.) of 91.9 (60.3-140.0) nmol. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Calderon SN, Rothman RB, Porreca F, et al. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. Journal of Medicinal Chemistry, 1994, 37(14): 2125-2128. 2. Quirion B, Bergeron F, Blais V, et al. The Delta-Opioid Receptor; a Target for the Treatment of Pain. Frontiers in Molecular Neuroscience, 2020, 13: 52. 3. Bilsky EJ, Calderon SN, Wang T, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. Journal of Pharmacology and Experimental Therapeutics, 1995, 273(1): 359-366. |
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Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
