LY2608204
Catalog No.
B2160
GK activator
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LY2608204 is a novel and potent activates of glucokinase (GK) with the EC50 value of 42nM [1].
LY2608204 has shown the novel and potent stimulant of glucokinase (GK) with the EC50 value of 42nM at lower glucose concentrations. In addition, LY2608204 has been reported to activate glucose metabolism with the EC50 value of 579nM in rat insulinoma INS1-E cell lines. Apart from these, LY2608204 has been revealed to lower plasma glucose in a dose-dependent fashion at the levels of fasted and postprandial [1].
References:
[1] KJ Filipski, BD Stevens . Glucokinase activators in development .2012 books
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 559.81 |
| Cas No. | 1234703-40-2 |
| Formula | C28H37N3O3S3 |
| Solubility | ≥28.35 mg/mL in DMSO; insoluble in H2O; ≥26.2 mg/mL in EtOH |
| Chemical Name | (1R,2S)-2-cyclohexyl-1-(4-cyclopropylsulfonylphenyl)-N-[5-(2-pyrrolidin-1-ylethylsulfanyl)-1,3-thiazol-2-yl]cyclopropane-1-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1CCC(CC1)C2CC2(C3=CC=C(C=C3)S(=O)(=O)C4CC4)C(=O)NC5=NC=C(S5)SCCN6CCCC6 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | LY2608204 is an activator of glucokinase (GK) with an EC50 value of 42 nM | |||||
| Targets | GK | |||||
| IC50 | 42 nM(EC50) | |||||
Quality Control & MSDS
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Chemical structure
