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Meropenem trihydrate

Catalog No.
B1217
Broad-spectum β-lactam antibiotic
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$61.00
In stock
25mg
$55.00
In stock
50mg
$66.00
In stock
100mg
$99.00
In stock
250mg
$198.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Meropenem trihydrate (SM-7338) is an active ingredient carbapenem antibiotic [1].

Meropenem trihydrate has shown the potent effect against gram-negative organisms with the MIC90 values of 0.03μM, 0.06μM, 0.06μM, 0.12μM,0.25μM, 0.12μM, 0.06μM, 0.12μM and 0.25μM for Escherichia coli (30), Klebsiella pneumonia(29), Klebsiella oxytoca (20), Enterobacter aerogenes (14), Enterobacter cloacae (29), Citrobacter freundii (20), Citrobacter diversus (12), proteus mirabilis (15) and Morganella morganii (15), respectively. In addition, Meropenem trihydrate has also been revealed to restrain gram-positive and anaerobic organisms with the MIC90 values of 0.008μM, 4μM and 0.015μM for Streptococcus pyogenes (20), Viridans group streptococci (27), Streptococcus pneumonia (15), respectively. Furthermore, Meropenem trihydrate has shown the different effect of pH on MIC, for example, the mean MIC values of 0.06μM and 0.03μM in pH5.5 and pH7.5, respectively [1].

References:
[1] Neu HC1, Novelli A, Chin NX.In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338.Antimicrob Agents Chemother. 1989 Jul; 33(7):1009-18.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt437.51
Cas No.119478-56-7
FormulaC17H31N3O8S
Solubility≥20.7 mg/mL in H2O with gentle warming; insoluble in EtOH; ≥49.2 mg/mL in DMSO
Chemical Name(4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate
SDFDownload SDF
Canonical SMILESCC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment:[1]

Animal models

Male Sprague-Dawley rats (250 ~ 350 g) with acute necrotizing pancreatitis

Dosage form

60 mg/kg

Once daily by intraperitoneal injection

Applications

Meropenem treatment significantly reduced hemorrhage and fat necrosis scores, as well as the incidence of pancreatic infection. When meropenem was combined with deferoxamine, improvements could be observed in all parameters including edema, acinar necrosis, inflammatory infiltrate, hemorrhage, fat necrosis, and perivascular inflammation. However, the difference between combined treatment and meropenem treatment did not reach to statistical significance.

Note

The technical data provided above is for reference only.

References:

1. Ateskan U, Mas MR, Yasar M, et al. Deferoxamine and meropenem combination therapy in experimental acute pancreatitis. Pancreas, 2003, 27(3): 247-252.

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