Moxidectin
Moxidectin is a macrocyclic lactone anthelmintic drug used to control or prevent parasitic worms. Its principal use is veterinary, in animals ranging from cats and dogs to horses and cattle. Moxidectin-susceptible parasites include Strongylus vulgaris in horses and Ostertagia ostertagi in cattle. In 2018, moxidectin was approved by FDA for treating onchocerciasis (river-blindness) caused by the parasitic worm Onchocerca volvulus.?
References:
1.?Rolfe PF, Dawson KL, Holm-Martin M. Efficacy of moxidectin and other anthelmintics against small strongyles in horses. Australian Veterinary Journal, 1998, 76(5): 332-334.
2.?Hubert J, Kerboeuf D, Cardinaud B, et al. Persistent efficacy of topical moxidectin against Dictyocaulus viviparus and Ostertagia ostertagi. Veterinary Parasitology, 1997, 68(1-2): 187-190.
3. Awadzi K, Opoku NO, Attah SK, et al. A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection. PLOS Neglected Tropical Diseases, 2014, 8(6): e2953.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 639.82 |
| Cas No. | 113507-06-5 |
| Formula | C37H53NO8 |
| Solubility | ≥128 mg/mL in EtOH; ≥129.4 mg/mL in DMSO; ≥3.27 mg/mL in H2O with gentle warming and ultrasonic |
| SDF | Download SDF |
| Canonical SMILES | CC(/C([H])=C([C@](O1)([H])[C@@](/C(C[C@@]21C[C@](O3)([H])C[C@@](O2)([H])C/C([H])=C(C[C@@](/C([H])=C([H])/C([H])=C([C@@]45O)\CO[C@]5([H])[C@@](O)([H])C(C)=C[C@@]4([H])C3=O)([H])C)\C)=N\OC)([H])C)\C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment:[1] | |
|
Animal models |
Shetland horses aged 1 to 32 years |
|
Dosage form |
0.4 mg/kg Anthelmintic drug in pastes applied to the base of the tongue |
|
Applications |
Moxidectin was highly effective in reducing faecal egg counts after treatment for at least 12 weeks and up to 16 weeks in most horses. |
|
Note |
The technical data provided above is for reference only. |
|
References: 1. Rolfe PF, Dawson KL, Holm-Martin M. Efficacy of moxidectin and other anthelmintics against small strongyles in horses. Australian Veterinary Journal, 1998, 76(5): 332-334. 2. Hubert J, Kerboeuf D, Cardinaud B, et al. Persistent efficacy of topical moxidectin against Dictyocaulus viviparus and Ostertagia ostertagi. Veterinary Parasitology, 1997, 68(1-2): 187-190. 3. Awadzi K, Opoku NO, Attah SK, et al. A randomized, single-ascending-dose, ivermectin-controlled, double-blind study of moxidectin in Onchocerca volvulus infection. PLOS Neglected Tropical Diseases, 2014, 8(6): e2953. |
|
Quality Control & MSDS
- View current batch:
Chemical structure
