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IM-12

Catalog No.
B4793
GSK-3β inhibitor, potent
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$83.00
In stock
10mg
$75.00
In stock
50mg
$290.00
In stock
200mg
$652.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

IM-12 is a potent inhibitor of GSK-3β with IC50 value of 53 nM [1].

Glycogen synthase kinase-3β (GSK-3β) is a proline-directed serine-threonine kinase and is involved in neuronal cell development, energy metabolism and body pattern formation. Inhibition of GSK-3β can cause β-catenin accumulation.

IM-12 is a potent GSK-3β inhibitor. In ReNcell VM cells, IM-12 significantly increased total β-catenin by 27% and at a concentration of 3 μM increased the β-catenin amount most. In ReNcell VM cells, IM-12 (3 μM) inhibited GSK-3β to a remaining activity of 27 ± 5%. Also, IM-12 significantly increased the cell doubling time to 26.5 ± 0.9 h and significantly inhibited cell proliferation. In ST14A cells, IM-12 caused an accumulation of β-catenin around the nucleus. In ReNcell VM cells transfected with TOPFlash, IM-12 increased TCF-activity. In cells transfected with TOP and pCAGGS-S33Y (a vector containing β-catenin), IM-12 significantly increased TCF-activity by 270%. In ReNcell VM cells, IM-12 significantly increased the level of βIIItub+ cells to 3.7 ± 0.7%, which suggested that IM-12 increased neuronal differentiation [1].

Reference:
[1].  Schm?le AC, Brennführer A, Karapetyan G, et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem, 2010, 18(18): 6785-6795.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt377.41
Cas No.1129669-05-1
FormulaC22H20FN3O2
Solubilityinsoluble in H2O; ≥18.85 mg/mL in DMSO; ≥5.23 mg/mL in EtOH with ultrasonic
SDFDownload SDF
Canonical SMILESFC1=CC=C(C=C1)CCNC2=C(C(N(C)C2=O)=O)C3=C(C)NC4=CC=CC=C34
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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