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Laminin (925-933)

Catalog No.
A1023
Extracellular matrix glycoprotein
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$253.00
In stock
1mg
$55.00
In stock
5mg
$154.00
In stock
10mg
$242.00
In stock
25mg
$330.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Laminin (925-933) is a peptide(Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg) derived from residues 925-933 of the laminin B1 chain that binds to the laminin receptor.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively)

The laminin beta 1 chain has 7 structurally distinct domains, which it shares with other beta chain isomers. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Figure1? Structure of Laminin

Figure2? Formula of LamininB1 (925-933)

Ref:

1.Ikonen J, Pikkarainen T, Savolainen ER, Tryggvason K (Feb 1989). "A Hpa I polymorphism in the human laminin B1 chain gene on 7q22". Nucleic Acids Res 17 (1): 473.

2.Roche KB, Moore JW, Surana RB, Wilson BE (May 1989). "Aortic root dilatation associated with partial trisomy 7(q31.2----qter)". Pediatr Cardiol 10 (1): 53–5.

3.Bonneau D, Huret JL, Godeau G, Couet D, Putterman M, Tanzer J, Babin P, Larregue M (Sep 1991). "Recurrent ctb(7)(q31.3) and possible laminin involvement in a neonatal cutis laxa with a Marfan phenotype". Hum Genet 87 (3): 317–9.?

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt967.06
Cas No.110590-60-8
FormulaC40H62N12O14S
SynonymsH2N-Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-OH
Solubility≥15.53 mg/mL in H2O; ≥17.77 mg/mL in EtOH; ≥48.35 mg/mL in DMSO
Chemical NameLaminin (925-933)
SDFDownload SDF
Canonical SMILESCCC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)CNC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(CS)N
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[1]

Cell lines

HT-1080 and CHO cells, as well as B16F10 murine melanoma cells

Reaction Conditions

100 and 300 μg/ml laminin (925-933)

Applications

Laminin (925-933) stimulated the attachment of HT-1080 and CHO cells to culture plates when used at concentrations of 100 and 300 μg/ml for 1 h incubation. In addition, laminin (925-933) (100 μg/ml; 5 h incubation) was found to be a chemoattractant for the B16F10 murine melanoma cells, showing about 30% of the maximal response observed with full-length laminin. Laminin (925-933) could compete with full-length laminin and inhibit chemotactic response of the cells to full-length laminin.

Note

The technical data provided above is for reference only.

References:

1. Graf J, Iwamoto Y, Sasaki M, et al. Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell, 1987, 48(6): 989-996.

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