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With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20℃; for 14h;
General procedure: To a solution of 3-anisyl pinacol borane (50mg, 0.21mmol) in DMF (1mL) was added N-bromosuccinimide (82mg, 0.46mmol). After stirring at room temperature for 14h, resultant solution was treated with 10% Na2S2O3 aq (10 ml) and was extracted with Et2O (10ml×3). The combined organic phase was washed with H2O (10ml×2) and brine (10ml×1) and dried over MgSO4. After removal of solvent under reduced pressure, the residue was chromatographed on silica gel with Hexane to afford 2-bromo-5-methoxyphenyl pinacol borate (57.3mg, 87% yield) as colorless oil
General procedure: To a solution of 3-anisyl pinacol borane (50 mg, 0.21 mmol)in DMF (1 mL) was added N-bromosuccinimide (82 mg, 0.46 mmol). After stirring at room temperature for 14 h, resultant solution was treated with 10% Na2S2O3aq (10 ml) and was extracted with Et2O (10 ml3). The combined organic phase was washed with H2O (10 ml2) and brine (10 ml1) and dried over MgSO4. After removal of solvent under reduced pressure, the residue was chromatographed on silica gel with Hexane to afford 2-bromo-5-methoxyphenyl pinacol borate (57.3 mg, 87% yield) as colorless oil
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