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[ CAS No. 94-41-7 ] {[proInfo.proName]}

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Chemical Structure| 94-41-7
Chemical Structure| 94-41-7
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Product Citations

Product Citations

Agarwal, Devesh S. ; Beteck, Richard M. ; Ilbeigi, Kayhan , et al. DOI: PubMed ID:

Abstract: A library of imidazo[1,2-a]pyridine-appended chalcones were synthesized and characterized using 1H NMR,13C NMR and HRMS. The synthesized analogs were screened for their antikinetoplastid activity against Trypanosoma cruzi, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Leishmania infantum. The analogs were also tested for their cytotoxicity activity against human lung fibroblasts and primary mouse macrophages. Among all screened derivatives, (E)-N-(4-(3-(2-chlorophenyl)acryloyl)phenyl)imidazo[1,2-a]pyridine-2-carboxamide was found to be the most active against T. cruzi and T. b. brucei exhibiting IC50 values of 8.5 and 1.35 μM, resp. Against T. b. rhodesiense, (E)-N-(4-(3-(4-bromophenyl)acryloyl)phenyl)imidazo[1,2-a]pyridine-2-carboxamide was found to be the most active with an IC50 value of 1.13 μM. All synthesized active analogs were found to be non-cytotoxic against MRC-5 and PMM with selectivity indexes of up to more than 50.

Keywords: antikinetoplastid ; ; drug likeliness properties ; ; neglected tropical diseases (NTDs) ; Trypanosoma brucei brucei ; Trypanosoma brucei rhodesiense

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Product Details of [ 94-41-7 ]

CAS No. :94-41-7 MDL No. :MFCD00003082
Formula : C15H12O Boiling Point : -
Linear Structure Formula :C6H5C(O)CHCHC6H5 InChI Key :DQFBYFPFKXHELB-VAWYXSNFSA-N
M.W : 208.26 Pubchem ID :637760
Synonyms :
benzylideneacetophenone;phenyl styryl ketone;NSC 26612;β-phenylacrylophenone;benzalacetophenone
Chemical Name :2-Benzalacetophenone

Safety of [ 94-41-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 94-41-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 94-41-7 ]

[ 94-41-7 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 538-28-3 ]
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  • [ 67374-06-5 ]
  • 2
  • [ 3199-50-6 ]
  • [ 94-41-7 ]
  • 2,4-diphenyl-6-(5-bromo-2-furyl)pyrylium perchlorate [ No CAS ]
  • 3
  • [ 784-04-3 ]
  • [ 94-41-7 ]
  • 2-(9-anthracenyl)-4,6-diphenylpyrylium perchlorate [ No CAS ]
  • 4
  • [ 20101-92-2 ]
  • [ 94-41-7 ]
  • [ 95734-21-7 ]
  • 5
  • [ 50-01-1 ]
  • [ 94-41-7 ]
  • [ 40230-24-8 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In ethanol; for 10h;Reflux; 1,3-Diphenyl propen-2-one (0.01mol) (1) were taken in a 250 mL round bottom flask and dissolved in ethanol (25 mL). To this guanidine chloride (0.01 mol) and ethanolic KOH (5 mL of 40 %) were added. The reaction mixture was refluxed for 10 h. The mixture was then poured into water (ice-cold) and neutralized with dil. HCl. After neutralization, the solid was filtered, washed with excess of water, dried and recrystallized from ethanol from ethanol to give pure product. Spectral data for compound 2: The IR of compound 2 exhibited nu (C=C) stretching = 1537-1494 cm-1, nu(N-H) (1 amine) stretching = 3302 cm-1 and 3475 cm-1, nu (C-N) stretching = 1220.98 cm-1, nu(C-H)(Sp2) stretching = 3180.72 cm-1. 1H NMR (400 MHz, DMSO-d6) delta ppm: 3.43 (s, 3H,-OCH3), 5.1 (s, 2H, -NH2), 7.0 to 8.0 (m, 20H, Ar-H and NH) [9].
  • 6
  • [ 34800-90-3 ]
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  • [ 70284-64-9 ]
  • 7
  • [ 50-01-1 ]
  • [ 94-41-7 ]
  • [ 1083-30-3 ]
  • [ 40230-24-8 ]
  • 8
  • [ 506-93-4 ]
  • [ 94-41-7 ]
  • [ 40230-24-8 ]
YieldReaction ConditionsOperation in experiment
35.6% With potassium methanolate; In ethanol; at 70℃; for 20.67h;Heating / reflux; 212.6 g (1.0 mol) of 98% 1,3-diphenyl-2-propen-1-one, 249.1 g (2.0 mol) of 98% guanidine nitrate and 1.51 of absolute ethanol are initially introduced at 70 C. 289.2 g (4.0 mol) of 97% potassium methoxide are then added in portions to the white suspension over the course of 40 minutes. After 20 hours at reflux, the yellow suspension is cooled to 50 C. and poured into 6 l of water, extracted with ethyl acetate, and concentrated by evaporation and the residue is recrystallized from isopropanol. 88.1 g of pale yellow crystals are obtained of the compound 1 [C00056] [00397] (=35.6% yield) with a melting point of 134-136 C.
  • 9
  • [ 51175-79-2 ]
  • [ 94-41-7 ]
  • [ 1138320-90-7 ]
  • 10
  • [ 102831-44-7 ]
  • [ 94-41-7 ]
  • C27H33NO7 [ No CAS ]
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