成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 82419-36-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 82419-36-1
Chemical Structure| 82419-36-1
Structure of 82419-36-1 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 82419-36-1 ]

Related Doc. of [ 82419-36-1 ]

Alternatived Products of [ 82419-36-1 ]
Product Citations

Product Details of [ 82419-36-1 ]

CAS No. :82419-36-1 MDL No. :MFCD00226105
Formula : C18H20FN3O4 Boiling Point : -
Linear Structure Formula :HOOC(O)C11H5ONF(CH3)C4H8N2CH3 InChI Key :GSDSWSVVBLHKDQ-UHFFFAOYSA-N
M.W : 361.37 Pubchem ID :4583
Synonyms :
Hoe-280;DL8280
Chemical Name :9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

Calculated chemistry of [ 82419-36-1 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 26
Num. arom. heavy atoms : 10
Fraction Csp3 : 0.44
Num. rotatable bonds : 2
Num. H-bond acceptors : 6.0
Num. H-bond donors : 1.0
Molar Refractivity : 101.83
TPSA : 75.01 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : Yes
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -8.78 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.49
Log Po/w (XLOGP3) : -0.39
Log Po/w (WLOGP) : 1.2
Log Po/w (MLOGP) : 0.98
Log Po/w (SILICOS-IT) : 1.47
Consensus Log Po/w : 1.15

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.99
Solubility : 3.72 mg/ml ; 0.0103 mol/l
Class : Very soluble
Log S (Ali) : -0.72
Solubility : 68.6 mg/ml ; 0.19 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -3.01
Solubility : 0.356 mg/ml ; 0.000986 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 3.63

Safety of [ 82419-36-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 82419-36-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 82419-36-1 ]

[ 82419-36-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 82419-36-1 ]
  • [ 93107-30-3 ]
YieldReaction ConditionsOperation in experiment
With triethanolamine; In 1,4-dioxane; To a cooled (15°-20° C.) Solution of Compound 2 (1.5 g) in dioxane (2 mL) is added dropwise a solution of Compound 5 (1.2 g) and TEA (1.1 mL) in dioxane (2.6 mL) at a rate which allows the temperature to be maintained below 20° C. The reaction is stirred at ambient temperature under N2 for 20 hours and the precipitate that is formed is filtered.
  • 2
  • copper(II) choride dihydrate [ No CAS ]
  • [ 82419-36-1 ]
  • [ 2848-01-3 ]
  • C33H33CuFN3O6P*H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
59.3% With sodium methylate; In methanol; for 3h;pH Ca. 6.8;Reflux; General procedure: Methanolic solution of CuCl2 2H2O (1.5 mmol) was added to a methanolic solution of 3-(diphenylphosphino)-propionic acid (L) (1.5 mmol) followed by the addition of a previously prepared methanolic solution of sparfloxacin (SFLH) (1.5 mmol) in presence of CH3ONa (1.5 mmol). The pH of the reaction mixture was adjusted to ～6.8. The resulting solution was refluxed for 3 h on a water bath, followed by concentrating to half of its volume. A fine, green amorphous product obtained was washed with ether/hexane/chloroform and dried in vacuum desiccators. The proposed reaction for the synthesis of complexes is shown in scheme 1 .
  • 3
  • oxovanadium(IV) sulfate [ No CAS ]
  • [ 82419-36-1 ]
  • [ 2848-01-3 ]
  • C33H33FN3O7PV [ No CAS ]
YieldReaction ConditionsOperation in experiment
64.18% In methanol; for 10h;pH Ca. 6.8;Reflux; General procedure: To a hot solution of VOSO4 (2) (5 mmol) in MeOH(25.0 mL), previously prepared methanolic solution ofligand 3-(diphenylphosphino)-propionic acid (1) (5 mmol)was added, with constant stirring. Then, alkaline methanolicsolution of ciprofloxacin (5 mmol) was added. The pH of thereaction mixture was adjusted to*6.8. The resulting greensolution was refluxed for 10 h and concentrated under vacuum.Upon addition of Et2O, a green solid precipitate wasobtained, which was collected by filtration, washed withEt2O and dried in vacuo (Gajera et al., 2015). General synthesisof complexes is shown in Scheme 1. Yield: 62.61 %.M.P:[300. Anal. Calcd (%). for C32H33FN3O6PV: C, 58.54;H, 5.07; N, 6.40; V, 7.76. Found (%): C, 58.24; H, 4.76; N,6.89; V, 7.26. UV-VIS in DMSO [kmax/nm (e/M-1 cm-1)]:421 (23,729), 584 (17,100), 807 (12,391). FT-IR: tmax(cm-1) m(C=O)pyridone 1628, m(CO2)asym 1586, m(CO2)-sym 1384, m = m(CO2)asym-m(CO2)sym = 202, m(V=O)952, m(M-O) 513 cm-1. ESI-MS (m/z):654.62 [M?].
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;