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[ CAS No. 816-94-4 ] {[proInfo.proName]}

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Chemical Structure| 816-94-4
Chemical Structure| 816-94-4
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Xuexiang Han ; Junchao Xu ; Ying Xu , et al. DOI: PubMed ID:

Abstract: The ionizable lipidoid is a key component of nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we devise an in situ construction method for the combinatorial synthesis of degradable branched (DB) lipidoids. We find that appending branch tails to inefficacious lipidoids via degradable linkers boosts mRNA delivery efficiency up to three orders of magnitude. Combinatorial screening and systematic investigation of two libraries of DB-lipidoids reveal important structural criteria that govern their in vivo potency. The DB-LNP demonstrates robust delivery of mRNA therapeutics and gene editors into the liver. In a diet-induced obese mouse model, we show that repeated administration of DB-LNP encapsulating mRNA encoding human fibroblast growth factor 21 alleviates obesity and fatty liver. Together, we offer a construction strategy for high-throughput and cost-efficient synthesis of DB-lipidoids. This study provides insights into branched lipidoids for efficient mRNA delivery.

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Product Details of [ 816-94-4 ]

CAS No. :816-94-4 MDL No. :MFCD00036905
Formula : C44H88NO8P Boiling Point : -
Linear Structure Formula :C36H72NPO8(CH2)8 InChI Key :NRJAVPSFFCBXDT-HUESYALOSA-N
M.W : 790.15 Pubchem ID :94190
Synonyms :
1,2-Distearoyl-sn-glycero-3-PC;DSPC;Coatsome MC 8080
Chemical Name :(R)-2,3-Bis(stearoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate

Safety of [ 816-94-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H317-H319 Packing Group:N/A
GHS Pictogram:
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