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[ CAS No. 78471-43-9 ] {[proInfo.proName]}

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Chemical Structure| 78471-43-9
Chemical Structure| 78471-43-9
Structure of 78471-43-9 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 78471-43-9 ]

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Product Details of [ 78471-43-9 ]

CAS No. :78471-43-9 MDL No. :MFCD04114319
Formula : C9H8Br2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :SGFACFBLUAWICV-UHFFFAOYSA-N
M.W : 307.97 Pubchem ID :22031079
Synonyms :

Calculated chemistry of [ 78471-43-9 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 13
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.22
Num. rotatable bonds : 3
Num. H-bond acceptors : 2.0
Num. H-bond donors : 0.0
Molar Refractivity : 58.26
TPSA : 26.3 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.03 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.7
Log Po/w (XLOGP3) : 3.02
Log Po/w (WLOGP) : 2.98
Log Po/w (MLOGP) : 3.39
Log Po/w (SILICOS-IT) : 3.39
Consensus Log Po/w : 3.1

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -3.8
Solubility : 0.0493 mg/ml ; 0.00016 mol/l
Class : Soluble
Log S (Ali) : -3.24
Solubility : 0.178 mg/ml ; 0.000579 mol/l
Class : Soluble
Log S (SILICOS-IT) : -4.57
Solubility : 0.00833 mg/ml ; 0.000027 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 2.09

Safety of [ 78471-43-9 ]

Signal Word:Danger Class:8
Precautionary Statements:P501-P260-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405 UN#:3261
Hazard Statements:H314-H290 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 78471-43-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 78471-43-9 ]

[ 78471-43-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 124-40-3 ]
  • [ 78471-43-9 ]
  • [ 868066-91-5 ]
YieldReaction ConditionsOperation in experiment
In methanol; for 18h;Heating; Reflux; A solution of methyl 4-bromo-2-(bromomethyl)benzoate (410 mmol) in MeNH2ZMeOH (1500 niL) was heated to reflux and stirred for 18 h. The reaction mixture was concentrated and the residue was purified by chromatography on silica eluting with petroleum ether / ethyl acetate (6:1 to 3:1) to afford the sub-titled compound (48.5 g).1H NMR (400 MHz, CDCl3): delta 7.63-7.61 (m, IH), 7.53-7.54 (m, 2H), 4.29 (s, 2H), 3.12 (s, 3H).
  • 2
  • [ 28466-26-4 ]
  • [ 78471-43-9 ]
  • [ 1315544-56-9 ]
YieldReaction ConditionsOperation in experiment
64% With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 110℃; for 1.5h; As shown in step 5-i of Scheme 5, methyl 4-bromo-2-(bromomethyl)benzoate (Compound 2018, 2.08 g, 6.75 mmol; prepared by reacting l-(4-bromo-2- methylphenyl)ethanone with NBS),lH-pyrazol-4-amine (561 mg, 6.75 mmol), and DIEA (873 mg, 1.18 mL, 6.75 mmol) were combined in DMF (7.78 mL) and heated at 110 C for 90 min. The reaction mixture was diluted with MeOH (60 mL) and the resulting white crystaline solid was collected by filtration and dried under vacuum to give 5-bromo-2-(lH- pyrazol-4-yl)isoindolin-l-one (Compound 2019, 1.21 g, 4.35 mmol, 64% yield): ESMS (Mu+Eta) 279.99
  • 3
  • [ 74-89-5 ]
  • [ 78471-43-9 ]
  • [ 868066-91-5 ]
YieldReaction ConditionsOperation in experiment
71% In tetrahydrofuran; at 50℃;Sealed tube; [00530] Intermediate 51 b: 5-bromo-2-methyl-isoindolin-1 -one[00531] To a reaction tube containing methyl 4-bromo-2-(bromomethyl)benzoate (1 .2g, 3.gmmol) was added methylamine (2.OM in THF, lOmL, 2Ommol). The tube was sealed and the mixture was stirred and heated at 50 C overnight. The mixture was then cooled to room temperature, filtered and the precipitate washed with THF. The filtrate was concentrated in vacuo and the residue waspurified by column chromatography using an eluent of 0-100% EtOAc in heptane to give 5-bromo-2- methyl-isoindolin-1-one (623mg, 2.7Smmol, 71% yield) as a white solid.1H NMR (CDCI3, 400MHz) O/ppm: 7.73-7.68 (1H, m), 7.64-7.56 (2H, m), 4.36 (2H, 5), 3.19 (3H, 5). MS Method 3: RT: 3.18 mi m/z226.0/228.0 [M+H]
68% With triethylamine; In tetrahydrofuran; at 100℃; for 12h;Sealed tube; Synthesis of 5-bromo-2-methylisoindolin-1-one (2) A mixture of methyl 4-bromo-2-(bromomethyl)benzoate (1, 1 g, 3.26 mmol), 2 M methylamine in tetrahydrofuran (1.95 mL, 3.9 mmol) and triethylamine (0.9 mL, 6.52 mmol) was heated at 100 C. for 12 h in a sealed tube. After completion of the reaction, the mixture was concentrated under reduced pressure. The obtained residue was diluted with ethyl acetate and washed with water. The organic was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was triturated with hexane to afford 5-bromo-2-methylisoindolin-1-one (2). Yield: 0.5 g, 68%; MS (ESI) m/z 226, 228 [M+1]+.
0.112 g In methanol; at 90℃; for 24h; Step A: 5-bromo-2-methylisoindolin-l-one [0234] Methyl 4-bromo-2-(bromomethyl)benzoate (0.153 g, 0.497 mmol) was suspended in methanamine (2M solution in MeOH, 2.484 mL, 4.97 mmol) and the mixture was heated to reflux (90C) for 24 hours. The reaction mixture was cooled, concentrated in vacuo, and dried under high vacuum to give the title compound (0.112 g). lU NMR (500 MHz, CDC13) delta ppm 3.19 (s, 3 H), 4.36 (s, 2 H), 7.57 - 7.62 (m, 2 H), 7.70 (d, J=8.30 Hz, 1 H); ESI-MS m/z [M+H]+ 226.3.
In methanol; ethanol;Reflux; To a solution of compound 1a (15 g, 50 mmol) in methanol (150 ml) was added methylamine (25 ml, 33% inethanol), and the reaction was refluxed overnight. After the organic solvent was drained off, the mixture was separatedby silica gel column chromatography (PE/EA= 3:1) to provide a yellow oily compound 1b.HNMR(CDCl3),7.5-7.7(m,3H),4.3(s,2H),3.1(s,3H).MS(ESI)m/z:225.9(M+H)+.
for 18h;Reflux; Methyl 4-bromo-2- (bromomethyl) benzoate (Formula 5-1, 2.5 g, 8.12 mmol) was dissolved in 2M methanamine (122 ml, 244 mmol, 30 eq) and then stirred at reflux for 18 hours. After completion of the reaction, Extracted with dichloromethane. The organic layer was washed with H 2 O, dried over anhydrous MgSO 4, and the solvent was removed under reduced pressure.Thereafter, the reaction mixture was separated and purified by MPLC (hexane / ethyl acetate; 70:30) to obtain a target compound (Formula 5-2).

  • 4
  • [ 78471-43-9 ]
  • [ 868066-91-5 ]
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