Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | ||||||
{[ item.p_purity ]} | {[ item.pr_size ]} | Inquiry |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]} |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]} | {[ item.pr_usastock ]} | in stock Inquiry - | {[ item.pr_chinastock ]} | {[ item.pr_remark ]} in stock Inquiry - | Login | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
Ouellette, Vincent ; Bouzriba, Chahrazed ; Alvarez, Atziri Corin Chavez , et al. RSC Med. Chem.,2024,15,3728-3745. DOI: 10.1039/D4MD00476K
More
Abstract: We developed first-in-class antimitotic prodrugs phenyl 4-(2-oxo-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs) bioactivated by cytochrome P450 (CYP) 1A1 that are highly selective toward several breast cancer cells. However, they show sparingly water solubility. Therefore, we replaced their phenyl ring B with a substituted pyridinyl group preparing novel pyridinyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PYRAIB-SOs) and their hydrochloride salts. Our results evidence that PYRAIB-SO hydrochloride salts show higher water solubility compared to their neutral and PAIB-SO counterparts by up to 625-fold. PYRAIB-SOs with a nitrogen atom at position 3 of the pyridinyl ring exhibited strong antiproliferative activity (IC50: 0.03-3.3 μM) and high selectivity (8-> 1250) toward sensitive CYP1A1-positive breast cancer cells and cells stably transfected with CYP1A1. They induce cell cycle arrest in the G2/M phase and disrupt microtubule dynamic assembly. Enzymatic assays confirmed that CYP1A1 metabolizes PYRAIB-SOs into their active form with in vitro hepatic half-lives (55-120 min) in rodent and human liver microsomes. Overall, this will allow to increase drug concentration for in vivo studies.
Keywords: Anticancer agents ; Antimitotics ; Antimicrotubule agents ; CYP1A1-activated prodrugs ; Pyridinyl 4-(2-oxo-alkylimidazolidin-1-yl)benzenesulfonates ; PYRAIB-SOs ; Pyridinyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates ; PYRIB-SOs ; Phenyl 4-(2-oxo-alkylimidazolidin-1-yl)benzenesulfonates ; PAIB-SOs ...More
Purchased from AmBeed: 328087-38-3 ; 109345-94-0 ; 74115-12-1 ; 36953-40-9 ; 74115-13-2
CAS No. : | 74115-12-1 | MDL No. : | MFCD00006379 |
Formula : | C5H4ClNO | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | TUIDQYRZDZRHPQ-UHFFFAOYSA-N |
M.W : | 129.54 | Pubchem ID : | 582305 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | |
Hazard Statements: | H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88% | 39a. 5-chloro-3-(N-t-butoxycarbonyl-2-(S)-azetidinylmethoxy)pyridine An ice-cooled solution of the compound from Example 7b (0.242 g, 1.20 mmol) was allowed to react with 3-chloro-5-hydroxypyridine (0.187 g, 1.40 mmol) under the conditions of Example 2a, except that DEAD was replaced with di-t-butylazodicarbonate, to yield the title compound (0.137 g, 88%) after purification on silica gel (ethyl acetate/hexane 2:1). MS (DCI/NH3) m/e: 299 (M+H)+. 1 H NMR (CDCl3, 300 MHz) δ: 8.25 (d, J=1.38 Hz, 1H), 8.21 (br. s, 1H), 7.29 (t, J=2.2 Hz, 1H), 4.53-4.51 (m, 1H), 4.34-4.33 (m, 1H), 4.13 (dd, J=10.3, 2.9 Hz, 1H), 3.91-3.86 (m, 2H), 2.51 (s, 3H), 2.38-2.29 (m, 2H), 1.43 (s, 9H). | |
39a. 5-chloro-3-(N-t-butoxycarbonyl-2-(S)-azetidinylmethoxy)pyridine An ice-cooled solution of the compound from Example 7b (0.242 g, 1.20 mmol) was allowed to react with 3-chloro-5-hydroxypyridine (0.187 g, 1.40 mmol) under the conditions of Example 2a, except that DEAD was replaced with di-t-butylazodicarbonate, to yield the title compound (0.137 g, 88%o) after purification on silica gel (ethyl acetate/hexane 2:1). MS (DCI/NH3) m/e: 299 (M+H)+. 1 H NMR (CDCl3,300 MHz) δ: 8.25 (d, J=1.38 Hz, 1H), 8.21 (br. s, 1H), 7.29 (t, J=2.2 Hz, 1H), 4.53-4.51 (m, 1H), 4.34-4.33 (m, 1H), 4.13 (dd, J=10.3, 2.9 Hz, 1H), 3.91-3.86 (m, 2H), 2.51 (s, 3H), 2.38-2.29 (m, 2H), 1.43 (s, 9H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With sulfuric acid; nitric acid; at 20℃; | Example 15A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and, at 0 C., 24 ml of concentrated nitric acid were added slowly. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound, which were used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H). |
82% | With sulfuric acid; nitric acid; at 0 - 20℃; | Example 7A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and, at 0 C., 24 ml of concentrated nitric acid were added slowly. The reaction was warmed to RT and stirred overnight. The reaction mixture was stirred into an ice/water mixture and it was stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound, which were used without further purification for the next reaction. LC-MS (Method 2): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H). |
82% | With sulfuric acid; nitric acid; at 0 - 20℃; | Example 12A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and, at 0 C., 24 ml of concentrated nitric acid were added slowly. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound, which were used without further purification for the next reaction. LC-MS (Method 2): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H). |
82% | With sulfuric acid; nitric acid; at 0 - 20℃; | With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The mixture was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H), 8.10 (d, 1H), 12.14 (br. 1H). |
82% | With sulfuric acid; nitric acid; at 0 - 20℃; | With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 00 C. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 mm. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction.10524] LC-MS (Method 1): R=0.60 mm10525] MS (ESneg): mlz=172.9/174.9 (M-H)10526] ?H-NMR (400 MHz, DMSO-d5): oe=7.71 (d, 1H);8.10 (d, 1H); 12.14 (bt 1H). |
82% | With sulfuric acid; nitric acid; at 0 - 20℃; | With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 2): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H). |
82% | With sulfuric acid; nitric acid; at 0 - 20℃; | With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulfuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 Mhz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H). |
82% | With sulfuric acid; nitric acid; at 0 - 20℃; | With ice cooling, 30 g of 5-chloropyridin-3-ol (232mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for 30 mm. The crystals were filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without thrther purification for the next reaction.10372] LC-MS (Method 2): R=0.60 mm10373] MS (ESneg): mlz=172.9/174.9 (M-H)j0374] ?H-NMR (400 MHz, DMSO-d5): oe=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (bt 1H). |
74% | With sulfuric acid; nitric acid; In water; at 5 - 20℃; for 3 - 144h;Product distribution / selectivity; | 5-Chloro-3-pyridinol (15.3 mmol) is dissolved in concentrated H2SO4 (15 ml). At 5 0C concentrated nitric acid (0.9 ml) is added. The reaction mixture is allowed to warm to room temperature over 6 days. The reaction solution is pored onto ice (50 ml) and diluted with water (200 ml). The precipitate is filtered, washed with water and dried at 40 0C in vacuo. 5-Chloro-2-nitro-pyridine-3-ol is obtained as yellow powder; mp. 97; LC- MS (method B): 1.35 min, 175.1 (M+H+).; 5-Chloro-3-pyridinol (382 mmol) is dissolved in concentrated H2SO4 (375 ml). At 5 0C concentrated nitric acid (25 ml) is added. The reaction is allowed to warm to room temperature over 3 hours. The reaction solution is pored onto ice water (5000 ml). The precipitate is filtered, washed with water and dried over night at 40 0C in vacuo. 5- Chloro-2-nitro-pyridine-3-ol is obtained as yellow powder in a yield of 74 %. Mp.: 97 0C; LC-MS (Method B): 1.35 min, 175.1 (MH+). |
67% | With sulfuric acid; nitric acid; at 5 - 20℃; for 3h; | 5-chloropyridin-3-ol(2.00 g, 15.4 mmol) was dissolved in concentrated H2SO4(15 mL) at 5 C. Concentrated nitric acid (1.0 mL) was then added. The reactionwas allowed to warm to room temperature over 3 hrs. The reaction solution waspoured onto ice water (25 mL). The resultant precipitate was filtered, washedwith water and dried overnight at 40 C in vacuo to afford was obtained as ayellow powder, (1.80g, 67%); H NMR (400 MHz, CDCI3) delta7.68 (d, 1H), 8.15 (d, 1H), 10.29 (s, 1H). |
With sulfuric acid; nitric acid; at 0 - 20℃;Cooling with ice; | Example 27A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, I equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method D): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H). | |
33 g | With sulfuric acid; nitric acid; at 0 - 20℃; | Example 7A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H). |
With nitric acid; | Example 7A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H) 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a solution of 5-chloropyridin-3-ol (3.64g, 28.1 mmol) in ACN (77mL) and DMF (7.73mL)vas added Cs2C03 ( 12.47g, 38.3mmol). The reaction mixture was stirred for l Omin and cooled down in an ice bath. A solution of methyl 5-(bromomethyl)thiophene- 2-carboxylate (6.0g, 25.5mmol) in ACN (20mL) was then added dropwise using an addition funnel. The reaction mixture was stirred for 2h and was then concentrated down, before being taken back in water and EtOAc. The organic phase was washed by water and brine, then dried over Na2S04 and filtered. Crude product was filtrated through a silica gel column with 30% EtOAc in hexanes, to afford the desired product (5.3g) as a light brown solid, LC-MS (ES) m/z = 284.0, 286.0 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With caesium carbonate; In N,N-dimethyl-formamide; at 25 - 70℃; | General procedure: A 4-halonitrobenzene (1.0?equiv), a hydroxyarene, and Cs2CO3 (1.1?equiv) were combined in DMF and the resulting heterogeneous mixture was stirred vigorously at 25?70?°C until all 4-halonitrobenzene was consumed (2?24?h). The reaction mixture was diluted with H2O and was adjusted to pH 5 with 2?N HCl (aq). The solution was extracted three times with EtOAc, and the organic layers were combined, washed once with brine solution, dried over MgSO4, filtered and concentrated in vacuo to furnish the desired diaryl ether that was used directly without further purification. |