成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 619-64-7 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 619-64-7
Chemical Structure| 619-64-7
Structure of 619-64-7 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 619-64-7 ]

Related Doc. of [ 619-64-7 ]

Alternatived Products of [ 619-64-7 ]
Product Citations

Product Citations

Anushree Mondal ; Pronay Roy ; Jaclyn Carrannatto , et al. DOI: PubMed ID:

Abstract: The prenylated-flavin mononucleotide-dependent decarboxylases (also known as UbiD-like enzymes) are the most recently discovered family of decarboxylases. The modified flavin facilitates the decarboxylation of unsaturated carboxylic acids through a novel mechanism involving 1,3-dipolar cyclo-addition chemistry. UbiD-like enzymes have attracted considerable interest for biocatalysis applications due to their ability to catalyse (de)carboxylation reactions on a broad range of aromatic substrates at otherwise unreactive carbon centres. There are now ～35[thin space (1/6-em)]000 protein sequences annotated as hypothetical UbiD-like enzymes. Sequence similarity network analyses of the UbiD protein family suggests that there are likely dozens of distinct decarboxylase enzymes represented within this family. Furthermore, many of the enzymes so far characterized can decarboxylate a broad range of substrates. Here we describe a strategy to identify potential substrates of UbiD-like enzymes based on detecting enzyme-catalysed solvent deuterium exchange into potential substrates. Using ferulic acid decarboxylase (FDC) as a model system, we tested a diverse range of aromatic and heterocyclic molecules for their ability to undergo enzyme-catalysed H/D exchange in deuterated buffer. We found that FDC catalyses H/D exchange, albeit at generally very low levels, into a wide range of small, aromatic molecules that have little resemblance to its physiological substrate. In contrast, the sub-set of aromatic carboxylic acids that are substrates for FDC-catalysed decarboxylation is much smaller. We discuss the implications of these findings for screening uncharacterized UbiD-like enzymes for novel (de)carboxylase activity.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;

Product Details of [ 619-64-7 ]

CAS No. :619-64-7 MDL No. :MFCD00002570
Formula : C9H10O2 Boiling Point : -
Linear Structure Formula :- InChI Key :ZQVKTHRQIXSMGY-UHFFFAOYSA-N
M.W : 150.17 Pubchem ID :12086
Synonyms :

Calculated chemistry of [ 619-64-7 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.22
Num. rotatable bonds : 2
Num. H-bond acceptors : 2.0
Num. H-bond donors : 1.0
Molar Refractivity : 43.17
TPSA : 37.3 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.16 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.73
Log Po/w (XLOGP3) : 2.89
Log Po/w (WLOGP) : 1.95
Log Po/w (MLOGP) : 2.25
Log Po/w (SILICOS-IT) : 2.01
Consensus Log Po/w : 2.16

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -2.86
Solubility : 0.206 mg/ml ; 0.00137 mol/l
Class : Soluble
Log S (Ali) : -3.33
Solubility : 0.0697 mg/ml ; 0.000464 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.54
Solubility : 0.429 mg/ml ; 0.00286 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.0

Safety of [ 619-64-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 619-64-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 619-64-7 ]

[ 619-64-7 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 619-64-7 ]
  • [ 6833-47-2 ]
YieldReaction ConditionsOperation in experiment
platinum (IV) oxide; platinum; In acetic acid; a) 4-ethylcyclohexanecarboxylic acid To a solution of 4-ethylbenzoic acid (10 g) in acetic acid (150 ml) was added platinum(IV) oxide (1.0 g), and the mixture was stirred at room temperature under a hydrogen atmosphere at 3 atm for 3 hr. The platinum catalyst was filtered off through a Celite pad, and the filtrate was concentrated to give the title compound (10.0 g).
  • 2
  • [ 619-64-7 ]
  • [ 38430-55-6 ]
  • 3
  • [ 619-64-7 ]
  • [ 84851-56-9 ]
  • 4
  • [ 619-64-7 ]
  • [ 201286-95-5 ]
  • 5
  • [ 619-64-7 ]
  • [ 369-26-6 ]
  • C17H16FNO3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
20% With trichlorophosphate; In acetonitrile; at 100℃; for 0.5h; POCI3 (44 mu, 0.470 mmol) was added to <strong>[369-26-6]methyl 3-amino-4-fluorobenzoate</strong> (53.0 mg, 0.313 mmol) and 4-ethylbenzoic acid (47.0 mg, 0.313 mmol) in MeCN (2 ml) and the mixture was heated at 100 °C for 30 min. Solvents were evaporated and residue purified by flash chromatography using 10-20percent) EtOAc in hexanes. Yield: 18.5 mg (20percent>); white solid. The amide from above (18.5 mg, 0.061 mmol) and Lawesson's reagent (32 mg, 0.078 mmol) in toluene (2 ml) was heated at 110 °C for 2 d. Solvent was evaporated and residue purified by flash chromatography using 20-35percent EtOAc in hexanes as eluent. Yield: 7.1 mg (39percent). Hydroxylamine potassium salt in MeOH (ca 1.7 M, 1.5 ml) was added to the ester from above and the mixture was heated at 60 °C for 45 min before quenched with AcOH (0.5 ml). The title compound was isolated by reversed phase chromatography (Kinetex CI 8, 5 muiotaeta, 21.2 x 100 mm, flow 25 ml/min, gradient 0.1percent TFA in water / acetonitrile over 15 minutes). Yield; 5.1 mg (72percent); white solid.
  • 6
  • [ 619-64-7 ]
  • [ 2632-14-6 ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;