成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 56602-33-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 56602-33-6
Chemical Structure| 56602-33-6
Structure of 56602-33-6 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 56602-33-6 ]

Related Doc. of [ 56602-33-6 ]

Alternatived Products of [ 56602-33-6 ]
Product Citations

Product Details of [ 56602-33-6 ]

CAS No. :56602-33-6 MDL No. :MFCD00011948
Formula : C12H22F6N6OP2 Boiling Point : -
Linear Structure Formula :- InChI Key :MGEVGECQZUIPSV-UHFFFAOYSA-N
M.W : 442.28 Pubchem ID :151348
Synonyms :
Chemical Name :((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Calculated chemistry of [ 56602-33-6 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 27
Num. arom. heavy atoms : 9
Fraction Csp3 : 0.5
Num. rotatable bonds : 5
Num. H-bond acceptors : 12.0
Num. H-bond donors : 0.0
Molar Refractivity : 95.3
TPSA : 76.84 ?2

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : Yes
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -5.19 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : 5.37
Log Po/w (WLOGP) : 7.13
Log Po/w (MLOGP) : 2.64
Log Po/w (SILICOS-IT) : -2.1
Consensus Log Po/w : 2.61

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 1.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -5.88
Solubility : 0.00058 mg/ml ; 0.00000131 mol/l
Class : Moderately soluble
Log S (Ali) : -6.74
Solubility : 0.000081 mg/ml ; 0.000000183 mol/l
Class : Poorly soluble
Log S (SILICOS-IT) : -1.89
Solubility : 5.68 mg/ml ; 0.0129 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 2.0
Synthetic accessibility : 4.32

Safety of [ 56602-33-6 ]

Signal Word:Danger Class:4.1
Precautionary Statements:P210-P240-P241-P261-P264-P271-P280-P302+P352-P304+P340+P312-P332+P313-P370+P378-P403+P233-P405-P501 UN#:1325
Hazard Statements:H228-H315-H335 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 56602-33-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56602-33-6 ]

[ 56602-33-6 ] Synthesis Path-Downstream   1~3

  • 1
  • (1S,2R)-1-(N-(t-butoxycarbonyl))-1,2-cyclopentanediamine [ No CAS ]
  • [ 17794-48-8 ]
  • [ 56602-33-6 ]
  • [ 7087-68-5 ]
  • [ 74-11-3 ]
  • [ 445478-99-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; trifluoroacetic acid; In hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; (27c) 4-Chlorobenzoic acid (258 mg) was dissolved in DMF (8 mL) prior to the addition of Hunig's base (1.0 mL). After cooling to 0 C., BOP Reagent (729 mg) was added. This was stirred for 15 min before (1S,2R)-1-(N-(t-butoxycarbonyl))-1,2-cyclopentanediamine, (27b), (300 mg) was added as a DMF solution (2 mL). The resulting mixture warmed to rt and was stirred overnight. EtOAc was added along with 1 N HCl solution. The EtOAc layer was washed with 1 N HCl, NaHCO3 solution, and brine. The EtOAc was dried (MgSO4), filtered, and concentrated. The resulting material was dissolved in CH2Cl2 (10 mL) and cooled to 0 C. TFA (1.2 mL) was added and the reaction was stirred for 2 h. This solution was concentrated prior to the addition of DMF (8 mL). After cooling to 0 C., Hunig's base (1 mL) and <strong>[17794-48-8][[3-(trifluoromethyl)benzoyl]amino]acetic acid</strong> (386 mg) were added. BOP Reagent (655 mg) was added next, and the mixture was stirred overnight. EtOAc was added along with 1 N HCl solution. The EtOAc layer was washed with 1 N HCl, NaHCO3 solution, and brine. The EtOAc was dried (MgSO4), filtered, and concentrated. This was stirred in 1:1 EtOAc/hexane and then filtered to give the title benzamide N-[2-[[(1S,2R)-2-[(4-chlorobenzoyl)amino]cyclopentyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide (310 mg) as a solid. MS found: (M+H)+=468.2.
  • 2
  • [ 117-78-2 ]
  • [ 56602-33-6 ]
  • [ 156-87-6 ]
  • [ 312731-66-1 ]
YieldReaction ConditionsOperation in experiment
57% In water; N,N-dimethyl-formamide; Example 3 Preparation of N-(3-hydroxypropyl)-2-anthraquinonecarboxamide (2) To a stirred suspension of <strong>[117-78-2]anthraquinone-2-carboxylic acid</strong> (Aldrich, 10.00 g, 39.64 mmol) in DMF (130 ml), was added (benzotriazol-1-yloxy)tris(dimethylamino)-phosphonium hexafluorophosphate (17.54 g, 39.66 mmol) and trethylamine (11.05 ml, 79.28 mmol). The resulting mixture (initially a clear green solution) was stirred at room temperature for 10 min. before dropwise addition of 3-amino-1-propanol (3.34 ml, 43.67 mmol). The reaction mixture (clear brown solution) was stirred at room temperature in the dark for 17 hours. The solution was poured in a thin stream into water (300 ml) containing some ice. The precipitated material was isolated by filtration and recrystallized from boiling 96percent ethanol (ca. 200 ml) and gave the title compound 2 as a bright yew solid (6.93 g, 57percent yield). 1H NMR (250 MHz, DMSO-d6) delta: 1.74 (2H, quintet, J=6.52 Hz, CH2), 3.25-3.44 (2H, m, CH2), 3.50 (2H, broad t, J=5.80 Hz, CH2), 4.53 (1H, broad s, OH), 7.76-8.00 (2H, m, Ar), 8.04-8.36 (4H, m, Ar), 8.56 (1H, d, J=1.55 Hz, Ar), 8.89 (1H, t, J=5.42 Hz, NH). 13C NMR (250 MHz, DMSO-d6) delta: 32.32, 36.96, 58.68, 125.50, 126.83, 126.85, 127.05, 132.79, 133.04, 133.08, 134.45, 134.66, 139.49, 164.62, 182.11.
  • 3
  • [ 4139-61-1 ]
  • [ 56602-33-6 ]
  • C15H8BrN3O3 [ No CAS ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;