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A mixture of pyridazin-3 -amine (9.51 g, 0.1 mol) and 2- <strong>[33142-21-1]ethyl 2-chloro-3-oxopropanoate</strong> (22.5 g,0.15 mol) in EtOH (20 mL) was stirred at reflux overnight. The mixture was allowed to cool to RT and concentrated in vacuo to remove EtOH. The residue was partitioned between water (100 mL) and ethyl acetate (100 mL). The organic layer was separated. The aqueous layer was extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine, dried over Na2S04 and filtered. The filtrate was concentrated in vacuo. The residue was slurried in isopropyl ether (50 mL) with stirring for 30 min, collected by filtration and dried in vacuo to afford ethyl imidazo[l,2-b]pyridazine-3-carboxylate (7.8 g, 40.8% yield).
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