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[ CAS No. 54221-96-4 ] {[proInfo.proName]}

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Chemical Structure| 54221-96-4
Chemical Structure| 54221-96-4
Structure of 54221-96-4 * Storage: {[proInfo.prStorage]}

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Product Citations

Product Citations

Nicholas O. Schneider ; Kendra Gilreath ; Daniel J. Burkett , et al. DOI:

Abstract: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase which plays a center role in the phosphorylation of a wide variety of proteins, generally leading to their inactivation. As such, GSK-3 is viewed as a therapeutic target. An ever-increasing number of small organic molecule inhibitors of GSK-3 have been reported. Phenylmethylene hydantoins are known to exhibit a wide range of inhibitory activities including for GSK-3β. A family of fourteen 2-heterocycle substituted methylene hydantoins (14, 17–29) were prepared and evaluated for the inhibition of GSK-3β at 25 μM. The IC50 values of five of these compounds was determined; the two best inhibitors are 5-[(4′-chloro-2-pyridinyl)methylene]hydantoin (IC50 = 2.14 ± 0.18 μM) and 5-[(6′-bromo-2-pyridinyl)methylene]hydantoin (IC50 = 3.39 ± 0.16 μM). The computational docking of the compounds with GSK-3β (pdb 1q41) revealed poses with hydrogen bonding to the backbone at Val135. The 5-[(heteroaryl)methylene]hydantoins did not strongly inhibit other metalloenzymes, demonstrating poor inhibitory activity against matrix metalloproteinase-12 at 25 μM and against human carbonic anhydrase at 200 μM, and were not inhibitors for Staphylococcus aureus pyruvate carboxylase at concentrations >1000 μM.

Keywords: nitrogen heterocycles ; glycogen synthase kinase 3β ; computational docking

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Product Details of [ 54221-96-4 ]

CAS No. :54221-96-4 MDL No. :MFCD05664030
Formula : C7H7NO2 Boiling Point : No data available
Linear Structure Formula :- InChI Key :YDNWTNODZDSPNZ-UHFFFAOYSA-N
M.W : 137.14 Pubchem ID :12325392
Synonyms :

Calculated chemistry of [ 54221-96-4 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.14
Num. rotatable bonds : 2
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 36.12
TPSA : 39.19 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.46 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.33
Log Po/w (XLOGP3) : 0.95
Log Po/w (WLOGP) : 0.9
Log Po/w (MLOGP) : -0.08
Log Po/w (SILICOS-IT) : 1.48
Consensus Log Po/w : 0.92

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.6
Solubility : 3.44 mg/ml ; 0.0251 mol/l
Class : Very soluble
Log S (Ali) : -1.36
Solubility : 5.99 mg/ml ; 0.0437 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -2.07
Solubility : 1.16 mg/ml ; 0.00849 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.41

Safety of [ 54221-96-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 54221-96-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54221-96-4 ]

[ 54221-96-4 ] Synthesis Path-Downstream   1~12

  • 1
  • [ 40473-07-2 ]
  • [ 68-12-2 ]
  • [ 54221-96-4 ]
YieldReaction ConditionsOperation in experiment
To a solution of the compound of Preparation 113 (5.6 g, 29.8 mmol) in anhydrous tetrahydrofuran (100 ml), at -78° C. and under nitrogen, was added n-butyllithium (1.6M in hexane, 19.5 ml), via syringe. The mixture was stirred at -78° C. for 30 min, before addition of N,N-dimethylformamide (2.5 ml, 32.8 mmol). The reaction mixture was allowed to warm to room temperature and stirred for 18 h, before being acidified with sulphuric acid (2M) and then neutralised by addition of sodium hydrogen carbonate. The mixture was concentrated in vacuo and the residue was extracted with ethyl acetate (4*150 ml). The combined extracts were dried (MgSO4) and concentrated in vacuo to give the title compound (3.0 g). 1H-NMR (CDCl3): 4.01-4.05 (3H), 6.95-7.00 (1H), 7.54-7.58 (1H), 7.70-7.76 (1H), 9.95-9.98 (1H)
  • 2
  • [ 54221-96-4 ]
  • [ 74-88-4 ]
  • [ 123506-64-9 ]
  • [ 123506-65-0 ]
  • 3
  • [ 54221-96-4 ]
  • [ 7144-05-0 ]
  • [1-(6-Methoxy-pyridin-2-yl)-meth-(E)-ylidene]-piperidin-4-ylmethyl-amine [ No CAS ]
  • 5
  • [ 110-91-8 ]
  • [ 54221-96-4 ]
  • [ 201852-49-5 ]
  • 4-[(E)-1-(6-Methoxy-pyridin-2-yl)-3-phenyl-allyl]-morpholine [ No CAS ]
  • 6
  • [ 54221-96-4 ]
  • [ 49579-12-6 ]
  • (S)-3-(2-chloro-phenyl)-6-fluoro-2-[2-(6-methoxy-pyridin-2-yl)-vinyl]-3H-quinazolin-4-one [ No CAS ]
  • 7
  • [ 54221-96-4 ]
  • [ 109434-09-5 ]
  • 2-(5-methoxy-2-nitro-phenyl)-1-(6-methoxy-pyridin-2-yl)-ethanol [ No CAS ]
  • 9
  • [ 54221-96-4 ]
  • (E)-1,2-Bis-(6-methoxy-pyridin-2-yl)-ethene-1,2-diol [ No CAS ]
  • 10
  • [ 54221-96-4 ]
  • (3,4-dimethoxy-benzyl)-triphenyl-phosphonium bromide [ No CAS ]
  • 2-(3,4-dimethoxystyryl)-6-methoxypyridine [ No CAS ]
  • 11
  • [ 54221-96-4 ]
  • [ 904324-31-8 ]
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