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In water (41 ml) suspension of <strong>[53848-17-2]2-bromo-6-methylaniline</strong> (4.17 g) was added concentrated hydrochloric acid (11.3mol/L, 5.95 mL). The reaction suspension, after dropping an aqueous solution of sodium nitrite (3.09 g, water 18 mL) at -3 C , this mixture was stirred for 30 minutes at -3 C. Under ice-cooling, after addition tetrafluoroborate sodium periodate solution (7.38 g, water 18 mL) stirred at room temperature for 3 hours. The precipitated solid was collected by filtration, to give compound Q4 (4.55 g) by drying. To chloroform suspension (45 mL) of potassium acetate compound Q4 (4.55 g) (3.91 g), and 18-crown-6 (0.42 g) was added, and this mixture was stirred at room temperature for 1 day. After completion of the reaction, ethyl acetate - it was separated by extraction with water, and the organic layer is dried over sodium sulfate, and then evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (elution solvent; hexane: ethyl acetate = 3:1) was obtained compound Q5 (2.61 g) by purifying.
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