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CAS No. : | 53145-38-3 | MDL No. : | MFCD01631573 |
Formula : | C7H6ClFO | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | QASFEHCRPLPGES-UHFFFAOYSA-N |
M.W : | 160.57 | Pubchem ID : | 2773581 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P305+P351+P338 | UN#: | |
Hazard Statements: | H227-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With boron tribromide; In dichloromethane; at -78 - 20℃; for 16h; | 2-Chloro-6-fluoro anisole (5 g, 31.13 mmol) was dissolved in DCM (300 mL) and cooled to about -78° C. To the solution was added BBr3 (7.35 mL, 77.8 mmol) in one portion. The reaction was warmed to r.t, stirred for about 16 hours and poured over ice to quench remaining BBr3. The material was partitioned between water and DCM (500 mL each). The aqueous layer was back extracted with DCM (200 mL), and the combined organics were dried (NaSO4), filtered and concentrated to give the product (4.60 g) as a dark oil. MS found 145.0 M-1 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With potassium carbonate; In tetrahydrofuran; at 20℃; for 3h; | Methyl iodide (850mul, 13.646mmol) and potassium carbonate (943mg, 6.824mmol) were added to <strong>[2040-90-6]2-chloro-6-fluorophenol</strong> (1.0g, 6.824mmol) in tetrahydrofuran (10ml) and the mixture was stirred at room temperature for 3 hours. The reaction mixture was partitioned between diethyl ether (50ml) and water (50ml). The organic phase was extracted and further washed with water (2 x 20ml) then dried over sodium sulphate and concentrated in vacuo to afford the title compound as a colourless liquid in 94percent yield, 1.03g.1HNMR(400MHz, CD3OD) delta: 3.90-3.91(s, 3H), 7.01-7.12(m, 2H), 7.18-7.21 (m, 1H) |
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