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With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,2-dimethoxyethane; water; toluene; for 7h;Reflux;
Compound 1 (2.7 g, 17 mmol) and compound 2 (8.0 g, 17 mmol)Was added 1,2-dimethoxyethane (200 ml) and toluene (400 ml)In addition, tetrakis (triphenylphosphine) palladium (0)(0.97 g, 0.84 mmol) and a 2 M aqueous sodium carbonate solution (67 ml) were added and the mixture was refluxed for 7 hours. After completion of the reaction,The solvent was distilled off under reduced pressure, and water was added. The obtained solid was filtered, washed with water and methanol, and dried under reduced pressure.The obtained crude product was purified by silica gel column chromatography (toluene), and the resulting solid was washed with methanol,And dried under reduced pressure to obtain Compound 3 (6.0 g, yield 70%) as a yellow solid.
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