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N-(2-Hydroxy-1,1-dimethylethyl)-2,4,5-trifluorobenzamide[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
In dichloromethane; N,N-dimethyl-formamide;
EXAMPLE I N-(2-Hydroxy-1,1-dimethylethyl)-2,4,5-trifluorobenzamide A solution of 19.4 g (110 mmol) of 2,4,5-trifluorobenzoic acid (JP 58,150,543 (Cl. C07C69) Sept. 7, 1983). 15.2 g (120 mmol) of oxalyl chloride and 250 ml of dichloromethane was treated with four drops of DMF, and the mixture was stirred at room temperature for four hours. The mixture was concentrated to a oil and was redissolved in 100 ml of dichloromethane. This solution was added dropwise to a solution of 19.6 g (240 mmol) of <strong>[15518-10-2]3-amino-2-methyl-1-propanol</strong> in 200 ml of dichloromethane at 5 C., and the reaction mixture was stirred at room temperature overnight. The solids were filtered, and the filtrate was washed with 5% sodium bicarbonate, 1N hydrochloric acid, and water. The organic layer was dried over magnesium sulfate and concentrated to give 24.5 g of the title compound, mp 114-116 C.
2-(2,4,5-Trifluoro anilino)-4,5-difluoro-benzoic Acid[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With n-butyllithium; diisopropylamine;
EXAMPLE T 2-(2,4,5-Trifluoro anilino)-4,5-difluoro-benzoic Acid Using General Method 1, the reaction of 2.5 M solution of n-BuLi in hexanes (21 mL, 53 mmol), diisopropylamine (7.2 mL, 51 mmol), <strong>[367-34-0]2,4,5-trifluoro-aniline</strong> (2.5 g, 17 mmol), and 2,4,5-trifluorobenzoic acid (3.0 g, 17 mmol) provided 4.54 g of the crude title compound.
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