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[ CAS No. 428-38-6 ] {[proInfo.proName]}

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Chemical Structure| 428-38-6
Chemical Structure| 428-38-6
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Product Details of [ 428-38-6 ]

CAS No. :428-38-6 MDL No. :MFCD08705803
Formula : C13H17N Boiling Point : -
Linear Structure Formula :- InChI Key :ZBYFQSPEUIVDTF-UHFFFAOYSA-N
M.W : 187.28 Pubchem ID :15637616
Synonyms :

Safety of [ 428-38-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 428-38-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 428-38-6 ]

[ 428-38-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 428-38-6 ]
  • [ 71831-21-5 ]
  • [ 1292291-10-1 ]
YieldReaction ConditionsOperation in experiment
98% With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; Preparation 55[4-(Spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methanolTo a stirred solution of 2,3-dihydrospiro[indene-1,4'-piperidine] (0.4 g, 1.78 mmol) in DMF (12 mL) is added Cs2CO3 (1.4 g, 4.4 mmol) and <strong>[71831-21-5][4-(bromomethyl)phenyl]methanol</strong> (0.36 g, 1.78 mmol) and the reaction mixture is stirred overnight at room temperature. The reaction mixture is poured into cold water and extracted with EtOAc (3.x.50 mL). The combined organic layer is washed with brine solution, dried over Na2SO4, and concentrated under vacuum. The crude material is purified by silica gel chromatography (gradient DCM/MeOH 8/2) to give the title compound (0.6 g, 98percent). ESI/MS m/z 308.40 (M+H)+.
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