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CAS No. : | 428-38-6 | MDL No. : | MFCD08705803 |
Formula : | C13H17N | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZBYFQSPEUIVDTF-UHFFFAOYSA-N |
M.W : | 187.28 | Pubchem ID : | 15637616 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 | UN#: | N/A |
Hazard Statements: | H315-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; | Preparation 55[4-(Spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methanolTo a stirred solution of 2,3-dihydrospiro[indene-1,4'-piperidine] (0.4 g, 1.78 mmol) in DMF (12 mL) is added Cs2CO3 (1.4 g, 4.4 mmol) and <strong>[71831-21-5][4-(bromomethyl)phenyl]methanol</strong> (0.36 g, 1.78 mmol) and the reaction mixture is stirred overnight at room temperature. The reaction mixture is poured into cold water and extracted with EtOAc (3.x.50 mL). The combined organic layer is washed with brine solution, dried over Na2SO4, and concentrated under vacuum. The crude material is purified by silica gel chromatography (gradient DCM/MeOH 8/2) to give the title compound (0.6 g, 98percent). ESI/MS m/z 308.40 (M+H)+. |
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