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[ CAS No. 4146-43-4 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 4146-43-4
Chemical Structure| 4146-43-4
Structure of 4146-43-4 * Storage: {[proInfo.prStorage]}

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Product Details of [ 4146-43-4 ]

CAS No. :4146-43-4 MDL No. :MFCD00007613
Formula : C4H10N4O2 Boiling Point : No data available
Linear Structure Formula :(CH2C(O)NHNH2)2 InChI Key :HCOMFAYPHBFMKU-UHFFFAOYSA-N
M.W : 146.15 Pubchem ID :72491
Synonyms :

Calculated chemistry of [ 4146-43-4 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.5
Num. rotatable bonds : 5
Num. H-bond acceptors : 4.0
Num. H-bond donors : 4.0
Molar Refractivity : 32.76
TPSA : 110.24 ?2

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -9.16 cm/s

Lipophilicity

Log Po/w (iLOGP) : -0.42
Log Po/w (XLOGP3) : -2.77
Log Po/w (WLOGP) : -2.25
Log Po/w (MLOGP) : -1.37
Log Po/w (SILICOS-IT) : -2.36
Consensus Log Po/w : -1.83

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 3.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : 1.33
Solubility : 3120.0 mg/ml ; 21.3 mol/l
Class : Highly soluble
Log S (Ali) : 1.01
Solubility : 1490.0 mg/ml ; 10.2 mol/l
Class : Highly soluble
Log S (SILICOS-IT) : 0.05
Solubility : 164.0 mg/ml ; 1.12 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 2.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.55

Safety of [ 4146-43-4 ]

Signal Word:Danger Class:4.1
Precautionary Statements:P210-P240-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P370+P378-P403+P233-P501 UN#:1325
Hazard Statements:H228-H302-H315-H319-H335 Packing Group:
GHS Pictogram:
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