* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With selenium(IV) oxide; In 1,4-dioxane; at 110℃; for 24h;
2-methyl-4-pyridinecarboxylic acid (5.0 g, 36.5 mmol),Selenium dioxide (10.1 g, 91.3 mmol) was added to 250 ml of dioxane, heated to 110 C., and reacted for 24 hours under magnetic stirring. The reaction was completed by TLC. The reaction solution was filtered while hot, and the solvent was evaporated under reduced pressure. The crude product was recrystallized from absolute ethanol and dried in vacuo to give 2-formyl-4-pyridinecarboxylic acid as a white solid in a yield of 72% and a purity of 98%.
72%
With iodine; dimethyl sulfoxide; at 150℃; for 1h;
2-Methylisonicotinic acid (10.0 g, 73.0 mmol), iodine (20.3 g, 80.3 mmol) was added to 120 mL of dimethyl sulfoxide, and the mixture was warmed to 150 C, and the mixture was stirred for 1 hour with magnetic stirring. The reaction was completed by TLC, and the reaction solution was cooled to room temperature and poured to 400 mL.In distilled water, the solid was precipitated, suction filtered, and washed with petroleum ether. The obtained crude product was recrystallized from anhydrous ethanol and dried in vacuo to give 2-formyl isoniconic acid, yield 72%, purity 97%.
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
120K+ Compounds
Competitive Price
1-2 Day Shipping
