成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 378211-85-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 378211-85-9
Chemical Structure| 378211-85-9
Structure of 378211-85-9 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 378211-85-9 ]

Related Doc. of [ 378211-85-9 ]

Alternatived Products of [ 378211-85-9 ]
Product Citations

Product Details of [ 378211-85-9 ]

CAS No. :378211-85-9 MDL No. :MFCD00297221
Formula : C7H5N3O2 Boiling Point : -
Linear Structure Formula :- InChI Key :DZPAOAZDQHZRGG-UHFFFAOYSA-N
M.W : 163.13 Pubchem ID :670824
Synonyms :

Calculated chemistry of [ 378211-85-9 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 9
Fraction Csp3 : 0.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 4.0
Num. H-bond donors : 1.0
Molar Refractivity : 39.95
TPSA : 67.49 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -7.16 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.73
Log Po/w (XLOGP3) : 0.19
Log Po/w (WLOGP) : 0.43
Log Po/w (MLOGP) : 0.23
Log Po/w (SILICOS-IT) : -0.19
Consensus Log Po/w : 0.28

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -1.46
Solubility : 5.65 mg/ml ; 0.0347 mol/l
Class : Very soluble
Log S (Ali) : -1.17
Solubility : 11.1 mg/ml ; 0.0683 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.08
Solubility : 13.7 mg/ml ; 0.0838 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.73

Safety of [ 378211-85-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280 UN#:N/A
Hazard Statements:H302-H317 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 378211-85-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 378211-85-9 ]

[ 378211-85-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 364594-66-1 ]
  • [ 378211-85-9 ]
  • [ 1367714-03-1 ]
  • 2
  • [ 378211-85-9 ]
  • 8-amino-2-(2-chloro-4-fluorophenyl)-2-azaspiro[4.5]decan-1-one [ No CAS ]
  • N-[(trans)-2-(2-chloro-4-fluorophenyl)-1-oxo-2-azaspiro[4.5]dec-8-yl]pyrazolo[1,5-a]pyrimidine-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
18% With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1-methyl-pyrrolidin-2-one; for 16.0h; To 8-amino-2-(2-chloro-4-fluorophenyl)-2-azaspiro[4.5]decan-1 -one (isomer 1 ) (44.5 mg, 150 muiotaetaomicronIota, Intermediate 112), in NMP (1 .0 ml) was added pyrazolo[1 ,5-a]pyrimidine-2-carboxylic acid (31 .8 mg, 195 mupiiotaomicronIota) in NMP (0.34 ml). HATU (74.1 mg) in NMP (0.5 ml) and N,N- diisopropylethylamine (50.4 mg, 0.390 mmol) in NMP (0.5 ml) were added. The resulting mixture was shaked for 16 h. The reaction mixture was filtered and the filtrate containing the crude product was subjected to preparative HPLC purification to give the title compound (13.4 mg, 18% yield).LC-MS (Method 5): Rt= 1 .02 min; MS (ESIpos): m/z = 442 [M+H]+
  • 3
  • [ 378211-85-9 ]
  • trans-4-amino-N-(2-chloro-4-fluorophenyl)cyclohexanecarboxamide hydrochloric acid salt [ No CAS ]
  • N-{trans-4-[(2-chloro-4-fluorophenyl)carbamoyl]cyclohexyl}pyrazolo[1,5-a]pyrimidine-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
9% With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; for 16.0h; To trans-4-amino-N-(2-chloro-4-fluorophenyl)cyclohexanecarboxamide hydrochloric acid salt (40.6 mg, 150 muiotaetaomicronIota, Intermediate I2) in NMP (1.0 ml) was added pyrazolo[1 ,5-a]pyrimidine-2- carboxylic acid (31 .8 mg, 195 muiotaetaomicronIota) in NMP (0.35 ml). HATU (74.1 mg) in NMP (0.5 ml) and N,N-diisopropylethylamine (50.4 mg, 0.390 mmol) in NMP (0.5 ml) were added. The resulting mixture was shaked for 16 h. The reaction mixture was filtered and the filtrate containing the crude product was subjected to preparative HPLC purification to give the title compound (6.2 mg, 9% yield). (0541) LC-MS (Method 5): Rt = 0.98 min; MS (ESIpos): m/z = 416 [M+H]+
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;