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CAS No. : | 377734-27-5 | MDL No. : | MFCD22381229 |
Formula : | C9H7BrO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GFZITIUEBBDMMN-UHFFFAOYSA-N |
M.W : | 243.05 | Pubchem ID : | 11436457 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94.3% | With manganese dioxide; In toluene; at 105℃; for 7.0h; | In a three-necked flask with a capacity of 3 liters, 253.11g of <strong>[307353-32-8]methyl 5-bromo-3-(hydroxymethyl)benzoate</strong> were placed and mixed with 2000 ml of toluene, and the resultant mixture was agitated to prepare a solution. The resultant solution was mixed with 44g of manganese dioxide, and the resultant reaction mixture liquid was heated to a temperature of 105C and agitated for 7 hours. The resultant reaction mixture liquid was allowed to be cooled to room temperature and filtered to remove a solid fraction therefrom, and the resultant filtrate was concentrated. The target compound, methyl 5-bromo-3-formylbenzoate was obtained in an amount of 236.79g which corresponded to a yield of 94.3%. The results of the 1H-NMR (200 MHz, delta ppm, CDCl3) of the resultant compound were as follows. 3.98 (s, 3H), 8.1 - 8.3 (m, 1H), 8.3 - 8.6 (m, 2H), 10.0 (s, 1H) |
With manganese(IV) oxide; In dichloromethane; at 20℃; | A mixture of <strong>[307353-32-8]methyl 3-bromo-5-(hydroxymethyl)benzoate</strong> (149 mg, 0.61 mmol) and manganese(IV) oxide (529 mg, 6.08 mmol), and CH2Cl2 (3 mL) was stirred at rt overnight. The mixture was filtered through Celite and the filter cake was washed with CH2Cl2. The filtrate was concentrated to afford the title compound. |