* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
1-[5-Fluoro-2-(1-methyl-piperidin-3-ylmethoxy)-phenyl]-3-(5-methyl-pyrazin-2-yl)-urea Steps 1-2: According to procedure for compound 300, using 1,4-difluoro-2-nitrobenzene and 1-methyl-3-hydroxymethyl piperidine.
With hydrogenchloride; In tetrahydrofuran; hexane;
EXAMPLE 1 Ethyl 3-(4-fluoro-2-nitroanilino)-1-methylpyrazole-4-carboxylate A solution of <strong>[21230-43-3]ethyl 3-amino-1-methylpyrazole-4-carboxylate</strong> (Helv. Chim. Acta (1959) 42 349) (17 g) in dry tetrahydrofuran (250 ml) was stirred under nitrogen at -10 C. n-Butyl lithium (75 ml of 1.84 molar solution in hexane) was added at -10 to -15 C. The mixture was stirred at -15 C. for 10 minutes and a solution of 2,5-difluoronitrobenzene (16 g) in dry tetrahydrofuran (50 ml) was added at -15 to -10 C. The solution was warmed at room temperature and stirred for 1 hour. The ink-blue solution was poured into 500 ml of a 1:1 mixture of hydrochloric acid (2 M) and ice-brine, extracted with chloroform (3*250 ml), washed with water (2*250 ml), dried with magnesium sulphate and evaporated to dryness. The brick-red residue was crystallized from ethanol (800 ml) to give the title compound having a m.p. of 162 C. The following compounds were similarly prepared using the above process.
ethyl 2-(4-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
STARTING MATERIAL SYNTHESIS EXAMPLE 8 In the same manner as in Starting Material Synthesis Example 4 and using <strong>[7311-95-7]ethyl 2-aminobenzo[b]thiophene-3-carboxylate</strong>, 2,5-difluoronitrobenzene and dimethyl sulfoxide, ethyl 2-(4-fluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate is obtained.
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
120K+ Compounds
Competitive Price
1-2 Day Shipping
