成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 27757-85-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 27757-85-3
Chemical Structure| 27757-85-3
Structure of 27757-85-3 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 27757-85-3 ]

Related Doc. of [ 27757-85-3 ]

Alternatived Products of [ 27757-85-3 ]
Product Citations

Product Citations

Robert Kaw?cki ; DOI: PubMed ID:

Abstract: N-Sulfenylimines (sulfenimines, thiooximes, N-alkylidenesulfenamides) were efficiently synthesized through the reaction of primary amines and disulfides with NBS or bromine. This reaction can be carried out in an open flask at room temperature without the need for any transition-metal-containing additives. The use of thiols instead of disulfides gave similar results. A wide range of amines were reacted with aryl and alkyldisulfides, resulting in the formation of sulfenimines in a yield of 44–99%.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; ; ;

Product Details of [ 27757-85-3 ]

CAS No. :27757-85-3 MDL No. :MFCD00005460
Formula : C5H7NS Boiling Point : No data available
Linear Structure Formula :H2NCH2C4H3S InChI Key :FKKJJPMGAWGYPN-UHFFFAOYSA-N
M.W : 113.18 Pubchem ID :34005
Synonyms :

Calculated chemistry of [ 27757-85-3 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 7
Num. arom. heavy atoms : 5
Fraction Csp3 : 0.2
Num. rotatable bonds : 1
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 31.99
TPSA : 54.26 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.56 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.4
Log Po/w (XLOGP3) : 0.61
Log Po/w (WLOGP) : 1.05
Log Po/w (MLOGP) : 0.46
Log Po/w (SILICOS-IT) : 2.18
Consensus Log Po/w : 1.14

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.39
Solubility : 4.63 mg/ml ; 0.0409 mol/l
Class : Very soluble
Log S (Ali) : -1.32
Solubility : 5.37 mg/ml ; 0.0475 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.65
Solubility : 2.52 mg/ml ; 0.0222 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.61

Safety of [ 27757-85-3 ]

Signal Word:Danger Class:8
Precautionary Statements:P264-P271-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P233-P501 UN#:2735
Hazard Statements:H227-H314 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 27757-85-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27757-85-3 ]

[ 27757-85-3 ] Synthesis Path-Downstream   1~12

  • 1
  • [ 27757-85-3 ]
  • [ 877173-84-7 ]
  • [ 924902-39-6 ]
YieldReaction ConditionsOperation in experiment
92% With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 80℃; for 16.0h; To a solution of 3-bromo-7-chloropyrazolo[1 ,5-a]pyrimidine (9.63 g, 41.5 mmol) and diisopropylethylamine (10.9 ml_, 62.3 mmol) in 2-propanol (42 ml_) was added 2- EPO <DP n="47"/>(aminomethyl)thiophene (5.6 g, 49.8 mmol): After heating for 16 h at 80 0C, the reaction mixture was concentrated and the residue partitioned between dichloromethane and water. After separation, the organic phase was washed with 10% citric acid and brine, dried and concentrated to yield the desired 3-bromo-7-(2- thiophenemethylamino)pyrazolo[1 ,5-a]pyrimidine (11.49 g, 92%) as a brown solid. HPLC 99%; 1H NMR (250 MHz, CDCI3) delta 8.88 (t, J = 6.4 Hz, 1H), 8.25 (s, 1H), 8.18 (d, J = 5.3 Hz, 1 H), 7.38 (dd, J = 1.3, 5.1 Hz, 1H), 7.13 (dd, J = 1.3, 3.4 Hz, 1H), 6.95 (dd, J = 3.4, 5.1 Hz, 1H), 6.29 (d, J = 5.3 Hz, 1H), 4.80 (d, J = 6.4 Hz, 2H); 13C NMR (62.9 MHz, CDCI3) delta 150.5, 146.7, 145.5, 143.1, 140.8, 126.8, 126.2, 125.4, 86.5, 81.0, 40.0; MS (APCI) 311/309 [M+H]+.
  • 2
  • [ 4795-29-3 ]
  • [ 7154-73-6 ]
  • [ 2038-03-1 ]
  • [ 4572-03-6 ]
  • [ 27757-85-3 ]
  • [ 109-12-6 ]
  • [ 3731-53-1 ]
  • [ 107-10-8 ]
  • [ 7663-77-6 ]
  • [ 6628-04-2 ]
  • [ 2620-50-0 ]
  • polystyrene carboxaldehyde resin [ No CAS ]
  • [ 5071-96-5 ]
  • [ 617-89-0 ]
  • [ 28466-26-4 ]
  • [ 42185-03-5 ]
  • [ 453-71-4 ]
  • [ 19293-58-4 ]
  • [ 75-04-7 ]
  • [ 62-53-3 ]
  • [ 1003-03-8 ]
  • [ 51387-90-7 ]
  • [ 74-89-5 ]
  • [ 100-46-9 ]
  • [ 4152-90-3 ]
  • [ 68-41-7 ]
  • C9H8FN2O3Pol [ No CAS ]
  • C10H10FN2O3Pol [ No CAS ]
  • C11H12FN2O3Pol [ No CAS ]
  • C14H10FN2O3Pol [ No CAS ]
  • C11H8FN4O3Pol [ No CAS ]
  • C12H8FN4O3Pol [ No CAS ]
  • C13H10FN2O4Pol [ No CAS ]
  • C15H12FN2O3Pol [ No CAS ]
  • C14H11FN3O3Pol [ No CAS ]
  • C13H14FN2O3Pol [ No CAS ]
  • C13H10FN2O3PolS [ No CAS ]
  • C13H16FN2O4Pol [ No CAS ]
  • C13H14FN2O4Pol [ No CAS ]
  • C16H14FN2O4Pol [ No CAS ]
  • C11H9FN3O5Pol [ No CAS ]
  • C15H11ClFN2O3Pol [ No CAS ]
  • C17H17FN3O3Pol [ No CAS ]
  • C14H17FN3O3Pol [ No CAS ]
  • C14H17FN3O4Pol [ No CAS ]
  • C15H19FN3O3Pol [ No CAS ]
  • C16H12FN2O5Pol [ No CAS ]
  • C18H13FN3O3Pol [ No CAS ]
  • C15H17FN3O4Pol [ No CAS ]
  • C16H22FN4O3Pol [ No CAS ]
YieldReaction ConditionsOperation in experiment
A library of compounds in which R4 was various groups having the formula [CONHR ?] was prepared by the process described above using 4-fluoro-3-nitrobenzoic acid, as follows: [72] Aldehyde resin was mixed with a primary amine (R17-NH2) in [DICHLOROETHANE] (DCE), triethylorthoformate (TEOF), and DMF (containing [1%] acetic acid) in a 1: 1: 1 ratio. After shaken overnight, sodium triacetoxyborohydride (20 eq. ) dissolved in DMF was added (Abdel-Magid, A. F. , et al., Tetrahedron Lett, 3 1: 5595-5598 (1990) ). After the mixture was shaken at room temperature overnight, the resin was filtered and washed with DMF (3 x 5 mL), [MEOH] [(3 X 5] mL), DMF [(3 X 5] mL), [MEOH] [(3 X 5] mL), and [CH2CL2] [(3 X 5] mL). The resin was washed twice with 5 mL DMF containing [1%] Hunig's base. To the filtered resin was added a mixture of 4-fluoro-3-nitrobenzoic acid (FNBA, 10 eq. ) and diisopropylcarbodiimide (DIC, 5 eq. ) in 2: 1 DMF : DCM. After shaking at room temperature overnight, the resin was filtered and washed with DMF (3 x 5 mL) and [CH2C12] (3 x 5 mL). [73] The resin was shaken with a primary amine [(R2-NH2)] in DMF for 8 hrs, filtered, and washed with DMF (6 x 5 mL), [MEOH] [(3 X 5] mL), and CH2C12 (3 x 5 mL). The aryl nitro group was reduced by the addition of tin (II) chloride dihydrate (20 eq. , >2 M) and N-methyl morpholine (NMM, 20 eq. ) in N-methyl pyrrolidinone (NMP). After shaken at room temperature overnight, the resin was filtered and washed with NMP (3 x 5 mL), [MEOH] (3 x 5 mL), and [CH2CI2 (3 X 5] mL). The resulting resin was shaken at room temperature with cyanogen bromide (5 eq. ) overnight, filtered, and washed with CH2Cl2 (3 x 5 mL), [MEOH] (3 x 5 mL), and CH2CI2 (3 x 5 mL). To produce a free amine, the resin was shaken for 30 min. in CHCl2 with the addition of sodium methoxide in methanol, filtered, and washed with CH2Cl2 [(4 X 5] mL). [[74]] In the final diversification step, the resin was heated at 500 C in DMF with a mono- substituted epoxide [[RLCH (-CH2O-)].] After shaking for 2 to 4 days the resin was filtered and washed with DMF (5 x 5 mL), [MEOH] [(3 X 5] mL), and CH2Cl2 (3 x 5 mL). T he resin-bound benzimidazole was cleaved from the solid-support by treatment with TFA: [CH2C12] (2: 3) for 1 hour at room temperature.
  • 3
  • [ 27757-85-3 ]
  • [ 383132-31-8 ]
  • [ 1121056-60-7 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20.0℃; for 0.5h; A mixture of <strong>[383132-31-8]5-bromo-7-chloroindole-2-carboxylic acid</strong> (1.02 g, 3.71 mmol), 2- thiophenemethylamine (418.5 muL, 4.08 mmol), N, N-di-isopropylethylamine (1.94 mL, 11.12 mmol), and PyBroP (1.90 g, 4.08 mmol) was stirred in DMF (15 mL) at room temperature for 30 min. The mixture was diluted with EtOAc (150 mL) and washed successively with 2N HCl (2 x 50 mL), saturated aqueous NaHCO3 (50 mL), and brine (50 mL). The organic phase was dried (MgSO4), and filtered through a small pad of silica gel. Concentration of the solvent gave 5-bromo-7-chloro-lH-indole-2-carboxylic acid (thiophen-2-ylmethyl)-amide (1.50 g) as a white solid which was used for the next step without further purification. 1H NMR (d6-DMSO, 300 MHz) delta 4.67 (d, 2H, J - 5.9 Hz), 6.97 (dd, IH, J = 3.5, 5 Hz), 7.06 (dd, IH, J = 1.2, 3.5 Hz), 7.19 (s, IH), 7.41 (dd, IH, J = 1.2, 5 Hz), 7.46 (d, IH, J = 1.5 Hz), 7.86 (d, IH, J = 1.5 Hz), 9.21 (t, IH, J = 5.9 Hz), 1 1.98 (s, IH); MS (ESI) m/z = 368.9, 370.9 (MH+).
  • 4
  • [ 27757-85-3 ]
  • [ 171178-50-0 ]
  • [ 1134169-38-2 ]
YieldReaction ConditionsOperation in experiment
48% 795 mg (5.0 mmol) of 2,6-difluoro-nicotinic acid were dissolved in thionyl chloride (15 ml) and the solution was heated for 2 h at 80 C. Concentration in vacuo was then carried out and the residue was taken up in dioxane (15 ml). 566 mg (5.0 mmol) of thiophen-2-yl-methanamine were then added and the mixture was stirred for 1 h at RT. Concentration in vacuo was then carried out and the residue was taken up in EA, washed with water, a sat. aq. Na2CO3 sol., water again and brine, dried over Na2SO4, filtered and concentrated in vacuo. CC (hexane/EA 7:3) of the residue yielded 605 mg (2.4 mmol, 48%) of 2,6-difluoro-N-(thiophen-2-ylmethyl)nicotinamide.
  • 5
  • [ 27757-85-3 ]
  • [ 3314-30-5 ]
  • C13H11N3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; at 20℃; for 3h; General procedure: 2-(2-Aminomethyl)thiophene (5 mmol) dissolved in 5 mL of methanol was added dropwise to methanolic solution of 2-imidazole carbaldehyde (5 mmol). The mixture was allowed to stir at room temperature for 3 h, followed by dropwise addition of sodium borohydride (10 mmol) in 10 mL of sodium hydroxide solution. The resulting solution was stirred for 3 h and concentrated under reduced pressure; the residue was then extracted with three 10 mL portions of chloroform. The combined extract was dried over anhydrous MgSO4 and filtered, and the solvent was removed under reduced pressure to yield an oily product (L1). Yield: 0.466 g (62percent)
  • 6
  • [ 27757-85-3 ]
  • [ 56844-12-3 ]
  • 6-bromo-N-(thiophen-2-ylmethyl)thieno[2,3-d]pyrimidin-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% In isopropyl alcohol; at 80℃; for 1h;Inert atmosphere; General procedure: Compound 1 (1.00 g, 4.01 mmol) was mixed with the benzylamine (2-3 eq.) and i-PrOH (2-10 mL) and agitated at 80 C for 1-50 h, under nitrogen atmosphere. Then the mixture was cooled to rt, concentrated in vacuo, diluted with water (50 mL) and diethyl ether (100 mL) or EtOAc (100 mL). After phase separation, the water phase was extracted with more diethyl ether (2×50 mL) or EtOAc (2×50 mL). The combined organic phases were washed with saturated aq NaCl solution (25-50 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude oil was purified by drying under reduced pressure to constant weight, by silica-gel column chromatography or crystallized as specified for each individual compound.
  • 7
  • [ 27757-85-3 ]
  • [ 6967-82-4 ]
  • 5-(thiophen-2-ylmethyl)phenanthridin-6(5H)-one [ No CAS ]
  • 8
  • [ 27757-85-3 ]
  • [ 6967-82-4 ]
  • 2-bromo-N-(thiophen-2-ylmethyl)benzamide [ No CAS ]
  • 9
  • [ 27757-85-3 ]
  • [ 1180-71-8 ]
  • 2-((1S,3aS,4aR,4bR,9aR,11aS)-1-(furan-3-yl)-9a-(hydroxymethyl)-4b,7,7,11a-tetramethyl-3,5-dioxotetradecahydroisobenzofuro[5,4-f]oxireno[2,3-d]isochromen-9-yl)-N-(thiophen-2-ylmethyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With montmorillonite K-10; In dichloromethane; for 10h;Sonication; General procedure: To a round-bottom flask was added montmorilloniteK-10 (0.3 g mmol-1), and 1 (2.0 mmol) in CH2Cl2 wasdispersed on K-10. Then the appropriate amine (3.6 mmol)was added dropwise and the mixture was sonicatedin an ultrasonic bath; the progress of the reaction wasmonitored by TLC and after completion of the reaction(10-12 h), the products were extracted by washing theK-10 with CH2Cl2. The organic phase was dried withNa2SO4, filtered and the solvent was removed in vacuo toyield the crude products. The crude products were purifiedby column chromatography over silica gel using 2-5%EtOH-CH2Cl2 as eluent to give analytically pure products3a-o. The products were characterized by correspondingspectroscopic data (1H and 13C NMR, and HRMS).
  • 10
  • [ 27757-85-3 ]
  • [ 209991-62-8 ]
  • [ 7188-38-7 ]
  • [ 28809-07-6 ]
  • C30H31F3N2O5S [ No CAS ]
  • 11
  • [ 27757-85-3 ]
  • [ 1001414-56-7 ]
  • 12
  • [ 27757-85-3 ]
  • [ 117-21-5 ]
  • 4-chloro-2-(thiophen-2-ylmethyl)isoindoline-1,3-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
71% With acetic acid; at 110℃; for 4h; General procedure: The starting materials 1 and 2 were commercially available (Energy Chemical, Shanghai, China).Compound 2 (3.72 mmol) was added to a stirred solution of compound 1 (3.38 mmol) in glacial aceticacid (10 mL). The reaction mixture was then stirred at 110 C for 4 h. After completion of the reaction,the solvent was evaporated, and the residue was purified on a silica gel column chromatography andeluted with ethyl acetate/petroleum ether (bp 60-90 C) (1:3, v/v) to give compounds 3.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;