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ethyl 2-(6-(dimethylamino)pyridin-3-yl)-2-(pyridin-2-yl)acetate[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
85%
With palladium diacetate; caesium carbonate; XPhos; In 1,4-dioxane; at 100℃; for 12h;Inert atmosphere; Schlenk technique;
General procedure: An oven-dried Schlenk tube was charged with Pd(OAc)2 (0.015 mmol, 3.4 mg), X-Phos (0.015 mmol, 7.2 mg), Cs2CO3 (0.9 mmol, 293 mg), substrate 1 (0.3 mmol) and 2 (0.4 mmol). The reaction vessel was evacuated and backfilled again with nitrogen gas, and 1,4-dioxane (1 mL) was added via syringe under nitrogen. The reaction mixture was stirred at 100 C for 12 hours. The reaction mixture was then cooled to room temperature and diluted with EtOAc. The crude was nextfiltered through a plug of celite, which was washed with ethyl acetate. The solution was concentrated and further purifiedby flash column chromatography to afford the corresponding product.
Chemistry
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