* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
(S)-N-(2,6-dimethylphenyl)-1-(5-fluoropentyl)piperidine-2-carboxamide[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 80℃; for 3h;
(S) -N- (2,6-dimethylphenyl) piperidine-2-carboxamide (1a) (5.0 g, 21.52 mmol)1-bromo-3-fluoro-pentane (4.37 g, 25.9 mmol)Potassium carbonate (4.46 g, 32.3 mmol),50 ml of N, N-dimethylformamide was added to the reaction flask,80 stirring 3h,The reaction was stopped;Add an equal volume of ice water to stir to precipitate a white solid which was filtered and the solid was washed with ice water (20 ml x 4) and dried to give a white solid;The white solid was dissolved in 30 ml of ethyl acetate,Add 4M hydrochloric acid to no longer white solid precipitation,filter,The solid was washed with ethyl acetate,(S) -N- (2,6-diethylphenyl) -1- (5-fluoropentyl) piperidine-2-carboxamide hydrochloride (37) (6.11 g 79.2percent) was dried.
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
120K+ Compounds
Competitive Price
1-2 Day Shipping
