成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 2628-16-2 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 2628-16-2
Chemical Structure| 2628-16-2
Structure of 2628-16-2 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 2628-16-2 ]

Related Doc. of [ 2628-16-2 ]

Alternatived Products of [ 2628-16-2 ]
Product Citations

Product Details of [ 2628-16-2 ]

CAS No. :2628-16-2 MDL No. :MFCD00075734
Formula : C10H10O2 Boiling Point : -
Linear Structure Formula :C2H3C6H4OCOCH3 InChI Key :JAMNSIXSLVPNLC-UHFFFAOYSA-N
M.W : 162.19 Pubchem ID :75821
Synonyms :

Calculated chemistry of [ 2628-16-2 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.1
Num. rotatable bonds : 3
Num. H-bond acceptors : 2.0
Num. H-bond donors : 0.0
Molar Refractivity : 48.03
TPSA : 26.3 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.5 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.26
Log Po/w (XLOGP3) : 2.52
Log Po/w (WLOGP) : 2.15
Log Po/w (MLOGP) : 2.47
Log Po/w (SILICOS-IT) : 2.5
Consensus Log Po/w : 2.38

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.61
Solubility : 0.403 mg/ml ; 0.00248 mol/l
Class : Soluble
Log S (Ali) : -2.72
Solubility : 0.31 mg/ml ; 0.00191 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.91
Solubility : 0.2 mg/ml ; 0.00123 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.42

Safety of [ 2628-16-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H317-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2628-16-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2628-16-2 ]

[ 2628-16-2 ] Synthesis Path-Downstream   1~12

  • 1
  • [ 2628-16-2 ]
  • [ 13031-43-1 ]
  • 2
  • [ 2628-16-2 ]
  • [ 66996-59-6 ]
  • Acetic acid 4-[(E)-2-(5-bromo-6-methoxy-naphthalen-2-yl)-vinyl]-phenyl ester [ No CAS ]
  • 3
  • [ 2628-16-2 ]
  • [ 65938-77-4 ]
  • N-(5-methyl-2-pyridinesulfonyl)(4-acetyloxyphenyl)aziridine [ No CAS ]
  • 5
  • [ 2628-16-2 ]
  • [ 13031-43-1 ]
  • [ 99-93-4 ]
  • [ 53744-50-6 ]
YieldReaction ConditionsOperation in experiment
With acetic anhydride; In palladium-carbon; EXAMPLE 1 This example illustrates the preparation of 4-acetoxystyrene oxide from 4-acetoxystyrene under the invention, the latter compound having been prepared from 4-hydroxyacetophenone (4-HAP) as an intermediate. A solution of 136.2g (1.0 mol) of 4-hydroxyacetophenone and 400 ml of acetic anhydride was heated at reflux for 3 h under a nitrogen atmosphere. The acetic acid and acetic anhydride was distilled overhead in vacuo (30-41C, 2.6 mm Hg). The remaining oil was then distilled in vacuo (132-134C, 2.0 mm Hg) to yield 169.7g (95.2%) of white crystals identified as 4 -acetoxyacetophenone. 4-Acetoxyacetophenone (100.0 g, 0.56 mol) was hydrogenated in a Fluidtron Reactor with 5% Pd/C (3.94 g) at 100 psig. The hydrogenation was carried out at 60C for 5.25 hours. The reactor was depressurized and the catalyst removed via filtration to afford 1-(4--acetoxyphenyl)ethanol as an oil (93.6 g).
  • 6
  • [ 3939-23-9 ]
  • [ 2628-16-2 ]
  • [ 1256379-23-3 ]
  • 7
  • [ 3939-23-9 ]
  • [ 2628-16-2 ]
  • [ 1256379-27-7 ]
  • 8
  • [ 2628-16-2 ]
  • [ 35354-29-1 ]
  • [ 42206-94-0 ]
YieldReaction ConditionsOperation in experiment
With N-ethylmorpholine;; thionyl chloride;palladium diacetate; In ethyl acetate; N,N-dimethyl-formamide; toluene; (E)-3,4',5-Triacetoxystilbene 3,5-Diacetoxybenzoic acid (8.022 g, 33.706 mmol) suspended in a mixture of toluene (130 mL), DMF (500 μL) and thionyl chloride (16.00 mL, 220.6 mmol) was heated at 100 C. for three hours under an argon gas atmosphere. The solvents were removed by vacuum distillation and the residue re-suspended in toluene (85 mL) and sonicated under vacuum to remove dissolved gases. 4-Acetoxystyrene (5.74 mL, 37.5 mmol), N-ethylmorpholine (4.31 mL, 33.9 mmol) and palladium diacetate (35 mg, 0.16 mmol, 0.46 mole %) were added and the reaction heated to reflux for 2 hours. Further palladium diacetate (116 mg, 0.52 mmol, 1.54 mole %) was added and the reaction left to reflux overnight. On return to room temperature, ethyl acetate (500 mL) was added, the solution was washed with 0.1 M HCl (2*300 mL) and water (300 mL) and then dried and evaporated to return a brown solid. Purification with column chromatography (isocratically eluted with 2:1 Et2O/hexane) gave 7.888 g of a white solid, shown by 1H NMR to be predominantly the desired adduct. Further chromatography (gradient eluted starting with 4:1 hexane/EtOAc and finishing with 2:1 hexane/EtOAc) returned pure (E)-3,4',5-triacetoxystilbene (6.071 g, 51%) as a white solid. Rf 0.29 (2:1 hexane/EtOAc); mp 112.5-113.0 C. (lit mp 116 C.); (δC (CDCl3) 2.27 (s, 9H, 3*OAc), 6.80 (pseudo t, 1H, J 2.1, 4'-H), 6.93 (d, 1H, J 16.3, Htrans), 7.03 (d, 1H, J 16.3, Htrans), 7.04-7.09 (m, 4H, 3-H, 5-H, 2'-H, 6'-H) and 7.44-7.47 (m, 2H, 2-H, 6-H); δC(CDCl3) 20.07, 113.39, 115.88, 120.88, 126.19, 126.64, 128.64, 133.45, 138.53, 149.46, 150.34, 167.91 and 168.30; m/z (ESI) 377 (MNa+, 100%), 378 (21).
  • 9
  • [ 2628-16-2 ]
  • [ 69655-76-1 ]
  • C80H72O28Si8 [ No CAS ]
  • 10
  • [ 2628-16-2 ]
  • [ 5460-32-2 ]
  • [ 880354-47-2 ]
YieldReaction ConditionsOperation in experiment
With tetrabutylammomium bromide; potassium acetate; palladium diacetate; In N,N-dimethyl-formamide; at 80℃; for 5h;Inert atmosphere; Sealed tube; General procedure: To a solution of tetrabutylammonium bromide (1.100 g, 3.33 mmol), potassium acetate (0.586 g, 3.57 mmol), and palladium acetate (0.025 g, 0.11 mmol) in DMF (20 mL) were added substituted iodobenzene (2.21 mmol) and 4-acetyloxystyrene (2.44 mmol). The reaction mixture was recharged with Argon and stirred at 80C for 5 h in a sealed tube. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous NaCl and concentrated in vacuo. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 10:3) to afford the intermediate substituted (E)-4-styrylphenyl acetate. To a solution of triethylamine (2.0 mL) in MeOH (5 mL) was added substituted (E)-4-styrylphenyl acetate (1.36 mmol). The reaction mixture was stirred at reflux temperaturefor 3 h. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous NaCl and concentrated in vacuo. The residue was purified by column chromatography on silica gel (dichloromethane/methanol, 10:0.3) to afford pure product.
  • 11
  • [ 887144-97-0 ]
  • [ 29181-50-8 ]
  • [ 2628-16-2 ]
  • C17H13F3N2O2 [ No CAS ]
  • 12
  • [ 887144-97-0 ]
  • [ 7584-05-6 ]
  • [ 2628-16-2 ]
  • C17H16F3NO2 [ No CAS ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;