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CAS No. : | 2480-23-1 | MDL No. : | MFCD00037754 |
Formula : | C6H13NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | AKCRVYNORCOYQT-YFKPBYRVSA-N |
M.W : | 131.17 | Pubchem ID : | 444080 |
Synonyms : |
|
Chemical Name : | N-Methyl-L-valine |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | (2S)-3-Methyl-2-methylamino-butanoic acid (5 g, 38.12 mmol) is added to a stirring solution of sodium hydroxide (76.2 mL of 1 M, 76.24 mmol). After complete dissolution, sodium carbonate (2.1 g, 19.82 mmol) is added followed by methyl chloroformate (3.18 mL, 41.17 mmol) at 0C over 40 minutes. The reaction mixture is stirred at rt for 4 hours, and then washed with diethyl ether (2x 75 ml). The aqueous layer is cooled to 0C, acidified to pH 1 -2 and extracted with CH2Cl2. The organic phase is dried over MgS04, filtered and concentrated to dryness to give the title compound (2S)-2- [methoxycarbonyl(methyl)amino]-3-methyl-butanoic acid (5.12g, 71%) as a clear oil. |