成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 2459-09-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 2459-09-8
Chemical Structure| 2459-09-8
Structure of 2459-09-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 2459-09-8 ]

Related Doc. of [ 2459-09-8 ]

Alternatived Products of [ 2459-09-8 ]
Product Citations

Product Citations

Anushree Mondal ; Pronay Roy ; Jaclyn Carrannatto , et al. DOI: PubMed ID:

Abstract: The prenylated-flavin mononucleotide-dependent decarboxylases (also known as UbiD-like enzymes) are the most recently discovered family of decarboxylases. The modified flavin facilitates the decarboxylation of unsaturated carboxylic acids through a novel mechanism involving 1,3-dipolar cyclo-addition chemistry. UbiD-like enzymes have attracted considerable interest for biocatalysis applications due to their ability to catalyse (de)carboxylation reactions on a broad range of aromatic substrates at otherwise unreactive carbon centres. There are now ～35[thin space (1/6-em)]000 protein sequences annotated as hypothetical UbiD-like enzymes. Sequence similarity network analyses of the UbiD protein family suggests that there are likely dozens of distinct decarboxylase enzymes represented within this family. Furthermore, many of the enzymes so far characterized can decarboxylate a broad range of substrates. Here we describe a strategy to identify potential substrates of UbiD-like enzymes based on detecting enzyme-catalysed solvent deuterium exchange into potential substrates. Using ferulic acid decarboxylase (FDC) as a model system, we tested a diverse range of aromatic and heterocyclic molecules for their ability to undergo enzyme-catalysed H/D exchange in deuterated buffer. We found that FDC catalyses H/D exchange, albeit at generally very low levels, into a wide range of small, aromatic molecules that have little resemblance to its physiological substrate. In contrast, the sub-set of aromatic carboxylic acids that are substrates for FDC-catalysed decarboxylation is much smaller. We discuss the implications of these findings for screening uncharacterized UbiD-like enzymes for novel (de)carboxylase activity.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;

Product Details of [ 2459-09-8 ]

CAS No. :2459-09-8 MDL No. :MFCD00006427
Formula : C7H7NO2 Boiling Point : -
Linear Structure Formula :C5NH4C(O)(OCH3) InChI Key :OLXYLDUSSBULGU-UHFFFAOYSA-N
M.W : 137.14 Pubchem ID :227085
Synonyms :

Calculated chemistry of [ 2459-09-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.14
Num. rotatable bonds : 2
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 35.52
TPSA : 39.19 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.52 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.56
Log Po/w (XLOGP3) : 0.87
Log Po/w (WLOGP) : 0.87
Log Po/w (MLOGP) : 0.33
Log Po/w (SILICOS-IT) : 1.19
Consensus Log Po/w : 0.96

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.55
Solubility : 3.86 mg/ml ; 0.0282 mol/l
Class : Very soluble
Log S (Ali) : -1.28
Solubility : 7.25 mg/ml ; 0.0528 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -2.07
Solubility : 1.16 mg/ml ; 0.00849 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.08

Safety of [ 2459-09-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2459-09-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 2459-09-8 ]
  • Downstream synthetic route of [ 2459-09-8 ]

[ 2459-09-8 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 2459-09-8 ]
  • [ 1690-75-1 ]
Reference： [1] Journal of Organic Chemistry, 1955, vol. 20, p. 1761,1765
[2] Archiwum Chemji i Farmacji, 1936, vol. 3, p. 109,113[3] Chemisches Zentralblatt, 1937, vol. 108, # II, p. 74
[4] Helvetica Chimica Acta, 1954, vol. 37, p. 1672,1676
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 2459-09-8 ]

Esters

Chemical Structure| 1570-45-2

[ 1570-45-2 ]

Ethyl isonicotinate

Similarity: 0.96

Chemical Structure| 16830-24-3

[ 16830-24-3 ]

Methyl 2-methylisonicotinate

Similarity: 0.93

Chemical Structure| 81660-73-3

[ 81660-73-3 ]

tert-Butyl isonicotinate

Similarity: 0.91

Chemical Structure| 106047-17-0

[ 106047-17-0 ]

Methyl 4-(pyridin-4-yl)benzoate

Similarity: 0.91

Chemical Structure| 6937-03-7

[ 6937-03-7 ]

Methyl 2-aminoisonicotinate

Similarity: 0.89

Related Parent Nucleus of
[ 2459-09-8 ]

Pyridines

Chemical Structure| 1570-45-2

[ 1570-45-2 ]

Ethyl isonicotinate

Similarity: 0.96

Chemical Structure| 16830-24-3

[ 16830-24-3 ]

Methyl 2-methylisonicotinate

Similarity: 0.93

Chemical Structure| 81660-73-3

[ 81660-73-3 ]

tert-Butyl isonicotinate

Similarity: 0.91

Chemical Structure| 106047-17-0

[ 106047-17-0 ]

Methyl 4-(pyridin-4-yl)benzoate

Similarity: 0.91

Chemical Structure| 55-22-1

[ 55-22-1 ]

4-Pyridinecarboxylic acid

Similarity: 0.90

; ;