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[ CAS No. 24277-39-2 ] {[proInfo.proName]}

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Chemical Structure| 24277-39-2
Chemical Structure| 24277-39-2
Structure of 24277-39-2 * Storage: {[proInfo.prStorage]}

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Product Details of [ 24277-39-2 ]

CAS No. :24277-39-2 MDL No. :MFCD00038273
Formula : C14H25NO6 Boiling Point : -
Linear Structure Formula :(CH3)3COCONHCH(COOC(CH3)3)(CH2)2COOH InChI Key :-
M.W : 303.35 Pubchem ID :-
Synonyms :
Boc-Glu-OtBu

Safety of [ 24277-39-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 24277-39-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24277-39-2 ]

[ 24277-39-2 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 5672-83-3 ]
  • [ 24277-39-2 ]
  • [ 157886-31-2 ]
  • [ 73872-73-8 ]
  • [ 63061-86-9 ]
  • 2
  • [ 24277-39-2 ]
  • [ 24835-08-3 ]
  • N-(tert-Butoxycarbonyl)-N'-(2-nitrobenzyl)-L-glutamine α-tert-butyl ester [ No CAS ]
  • 4
  • [ 24277-39-2 ]
  • [ 91229-86-6 ]
  • 5
  • [ 7724-12-1 ]
  • [ 24277-39-2 ]
  • tert-butyl N2-(tert-butoxycarbonyl)-N5-(2-cyanobenzo[d]thiazol-6-yl)glutaminate [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% solution of Boc-Glu-OtBu ( 303 mg, 1.0 mmol) was added N-methylmorpholine (82 muL, 1.0 mmol) and i-BuOCOCl (112 muL, 2.0 mmol) in tetrahydrofuran (2 mL), the mixture was stirred at 0 °C for 0.5 h. Then <strong>[7724-12-1]2-cyano-6-aminobenzothiazole</strong> (87 mg, 0.5mmol) in 2ml tetrahydrofuan was added. The mixture was stirred at room temperature overnight. Then the solution was evaporated under reduced pressure. The mixture was diluted with ethyl acetate and (50 mL) washed with saturated sodium bicarbonate solution, water and brine, dried over anhydrous MgSO4 and filtered. The crude product was purified by chromatography with ethyl acetate?hexane (1:2) as the eluents to afford a white solid, 83 mg, yield = 60percent. 1H-NMR (400 MHz, CDCl3) delta 9.87 (s, 1H), 8.79 (s, 1H), 8.12 (d, J = 8.9 Hz, 1H), 7.57 (d, J = 8.8 Hz, 1H), 5.48 (d, J = 7.8 Hz, 1H), 4.30 ? 4.17 (m, 1H), 2.58 ? 2.45 (m, 2H), 2.30 (m, J = 10.3, 7.1, 3.3 Hz, 1H), 1.85 (m, J = 16.2, 10.7, 4.7 Hz, 1H), 1.51 (s, 9H), 1.46 (s, 9H).
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