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CAS No. : | 24277-39-2 | MDL No. : | MFCD00038273 |
Formula : | C14H25NO6 | Boiling Point : | - |
Linear Structure Formula : | (CH3)3COCONHCH(COOC(CH3)3)(CH2)2COOH | InChI Key : | - |
M.W : | 303.35 | Pubchem ID : | - |
Synonyms : |
Boc-Glu-OtBu
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | solution of Boc-Glu-OtBu ( 303 mg, 1.0 mmol) was added N-methylmorpholine (82 muL, 1.0 mmol) and i-BuOCOCl (112 muL, 2.0 mmol) in tetrahydrofuran (2 mL), the mixture was stirred at 0 °C for 0.5 h. Then <strong>[7724-12-1]2-cyano-6-aminobenzothiazole</strong> (87 mg, 0.5mmol) in 2ml tetrahydrofuan was added. The mixture was stirred at room temperature overnight. Then the solution was evaporated under reduced pressure. The mixture was diluted with ethyl acetate and (50 mL) washed with saturated sodium bicarbonate solution, water and brine, dried over anhydrous MgSO4 and filtered. The crude product was purified by chromatography with ethyl acetate?hexane (1:2) as the eluents to afford a white solid, 83 mg, yield = 60percent. 1H-NMR (400 MHz, CDCl3) delta 9.87 (s, 1H), 8.79 (s, 1H), 8.12 (d, J = 8.9 Hz, 1H), 7.57 (d, J = 8.8 Hz, 1H), 5.48 (d, J = 7.8 Hz, 1H), 4.30 ? 4.17 (m, 1H), 2.58 ? 2.45 (m, 2H), 2.30 (m, J = 10.3, 7.1, 3.3 Hz, 1H), 1.85 (m, J = 16.2, 10.7, 4.7 Hz, 1H), 1.51 (s, 9H), 1.46 (s, 9H). |