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[ CAS No. 19847-12-2 ] {[proInfo.proName]}

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Chemical Structure| 19847-12-2
Chemical Structure| 19847-12-2
Structure of 19847-12-2 * Storage: {[proInfo.prStorage]}

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Product Citations

Product Citations      Expand+

Yuan, Gengyang ; Dhaynaut, Maeva ; Lan, Yu , et al. DOI: PubMed ID:

Abstract: Metabotropic glutamate receptor 2 (mGluR2) is a therapeutic target for several neuropsychiatric disorders. An mGluR2 function in etiology could be unveiled by positron emission tomography (PET). In this regard, 5-(2-fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide ([11C]13, [11C]mG2N001), a potent negative allosteric modulator (NAM), was developed to support this endeavor. [11C]13 was synthesized via the O-[11C]methylation of phenol 24 with a high molar activity of 212 ± 76 GBq/μmol (n = 5) and excellent radiochemical purity (>99%). PET imaging of [11C]13 in rats demonstrated its superior brain heterogeneity and reduced accumulation with pretreatment of mGluR2 NAMs, VU6001966 (9) and MNI-137 (26), the extent of which revealed a time-dependent drug effect of the blocking agents. In a nonhuman primate, [11C]13 selectively accumulated in mGluR2-rich regions and resulted in high-contrast brain images. Therefore, [11C]13 is a potential candidate for translational PET imaging of the mGluR2 function.

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Hegde, Pooja V. ; Aragaw, Wassihun W. ; Cole, Malcolm S. , et al. DOI: PubMed ID:

Abstract: Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen because of its sterilizing activity against non-replicating Mycobacterium tuberculosis (Mtb), but its mechanism of action has remained enigmatic. PZA is a prodrug converted by pyrazinamidase encoded by pncA within Mtb to the active moiety, pyrazinoic acid (POA) and PZA resistance is caused by loss-of-function mutations to pyrazinamidase. We have recently shown that POA induces targeted protein degradation of the enzyme PanD, a crucial component of the CoA biosynthetic pathway essential in Mtb. Based on the newly identified mechanism of action of POA, along with the crystal structure of PanD bound to POA, we designed several POA analogs using structure for interpretation to improve potency and overcome PZA resistance. We prepared and tested ring and carboxylic acid bioisosteres as well as 3, 5, 6 substitutions on the ring to study the structure activity relationships of the POA scaffold. All the analogs were evaluated for their whole cell antimycobacterial activity, and a few representative mols. were evaluated for their binding affinity, towards PanD, through isothermal titration calorimetry. We report that analogs with ring and carboxylic acid bioisosteres did not significantly enhance the antimicrobial activity, whereas the alkylamino-group substitutions at the 3 and 5 position of POA were found to be up to 5 to 10-fold more potent than POA. Further development and mechanistic anal. of these analogs may lead to a next generation POA analog for treating TB.

Keywords: Tuberculosis ; Pyrazinoic acid ; pyrazinamide

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Product Details of [ 19847-12-2 ]

CAS No. :19847-12-2 MDL No. :MFCD00049361
Formula : C5H3N3 Boiling Point : -
Linear Structure Formula :- InChI Key :PMSVVUSIPKHUMT-UHFFFAOYSA-N
M.W : 105.10 Pubchem ID :73172
Synonyms :
Pyrazinecarbonitrile

Calculated chemistry of [ 19847-12-2 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 8
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 3.0
Num. H-bond donors : 0.0
Molar Refractivity : 26.75
TPSA : 49.57 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.95 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.79
Log Po/w (XLOGP3) : -0.01
Log Po/w (WLOGP) : 0.35
Log Po/w (MLOGP) : -1.48
Log Po/w (SILICOS-IT) : 0.92
Consensus Log Po/w : 0.11

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.04
Solubility : 9.58 mg/ml ; 0.0911 mol/l
Class : Very soluble
Log S (Ali) : -0.58
Solubility : 27.5 mg/ml ; 0.262 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.67
Solubility : 2.26 mg/ml ; 0.0215 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.78

Safety of [ 19847-12-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 19847-12-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 19847-12-2 ]

[ 19847-12-2 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 19847-12-2 ]
  • [ 645-36-3 ]
  • [ 119165-68-3 ]
YieldReaction ConditionsOperation in experiment
1.49 g
Stage #1: With sodium methylate In methanol at 10 - 35℃; for 0.416667 h;
Stage #2: With acetic acid In methanol at 50℃; for 1 h;
Stage #3: With hydrogenchloride In methanolReflux		 Step 1:
2-(1H-Imidazol-2-yl)pyrazine
2,2-Diethoxyethanamine (3 g, 2.25 mmol) was dissolved in dry methanol (20 mL).
To this was added sodium methoxide (1.22 g, 22.5 mmol, as a 25percent solution in methanol).
After stirring for 25 minutes at room temperature, pyrazine-2-carbonitrile (2.37 g, 22.5 mmol) and acetic acid (1.35 g, 22.5 mmol) were added and the subsequent solution was stirred at 50° C. for 1 hour. MeOH (40 mL) and 6N HCl (12 mL) were added and the reaction was stirred at reflux overnight.
The reaction mixture was cooled to room temperature and partitioned between 1:1 Et2O and water (60 mL) and the layers were separated.
The aqueous layer was basified to pH 9/10 and extracted with 10percent MeOH in DCM.
The combined organic extracts were dried (MgSO4), filtered and concentrated to give the desired compound (1.49 g yellow solid).
1H NMR (400 MHz, MeOH-d4) δ ppm: 7.67 (s, 1H), 7.09 (d, J=1.8 Hz, 1H), 6.99 (d, J=2.5 Hz, 1H), 5.72 (s, 2H)
Reference： [1] Inorganic Chemistry, 2018, vol. 57, # 23, p. 14603 - 14616
[2] Patent: WO2012/93148, 2012, A1, . Location in patent: Page/Page column 36-37
[3] Patent: US2014/11802, 2014, A1, . Location in patent: Paragraph 0196; 0197
  • 2
  • [ 19847-12-2 ]
  • [ 22483-09-6 ]
  • [ 119165-68-3 ]
Reference： [1] Chemical Communications, 2015, vol. 51, # 12, p. 2425 - 2428
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