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CAS No. : | 186517-01-1 | MDL No. : | MFCD08276341 |
Formula : | C14H8Br2 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | BPRGLVVFWRNXEP-UHFFFAOYSA-N |
M.W : | 336.02 | Pubchem ID : | 22058906 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P280-P305+P351+P338 | UN#: | |
Hazard Statements: | H302 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene;Inert atmosphere; Reflux; | 6.28 g (0.02 mol) of intermediate G25-1, 2.66 g (0.01 mol) of 2,6-dibromofluorene,4.15 g (0.03 mol) of potassium carbonate, 50 ml of toluene, 30 ml of ethanol and 30 ml of water were mixed.The reaction was carried out by adding 0.23 g (0.0002 mol) of tetrakis(triphenylphosphine)palladium under a nitrogen atmosphere.The temperature was raised to reflux, the spot plate was monitored until the reaction was completed, the reaction was terminated, the reaction solution was spun dry, 100 ml of dichloromethane was added, and the solution was completely dissolved and passed through a silica gel column. The filtrate was added with 100 ml of water, washed with water, and the organic phase was separated and dried. It was boiled twice with ethanol and filtered to obtain 4.3 g of a white solid compound G25-2 in a yield of 60%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene;Inert atmosphere; Reflux; | 6.28 g (0.02 mol) of intermediate G26-1, 2.66 g (0.01 mol) of 2,6-dibromoindole, 4.15 g (0.03 mol) of potassium carbonate, 50 ml of toluene, 30 ml of ethanol and 30 ml of water were mixed under a nitrogen atmosphere. The reaction was carried out by adding 0.23 g (0.0002 mol) of tetrakis(triphenylphosphine)palladium, and the temperature was raised to reflux. The reaction was completed until the reaction was completed. The reaction was terminated, and the reaction solution was spun dry, and 100 ml of dichloromethane was added to dissolve it completely. The silica gel column and the filtrate were added with 100 ml of water, washed with water, and the organic phase was separated, dried, and then, then, and dried twice with ethanol and filtered to give 4.5 g of white solid compound G26-2, yield 61%. |