Alternatived Products of [ 1757-72-8 ]
Product Details of [ 1757-72-8 ]
CAS No. : | 1757-72-8 |
MDL No. : | MFCD00186065 |
Formula : |
C16H13NO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | YJOWMBICANYBLV-UHFFFAOYSA-N |
M.W : |
235.28
|
Pubchem ID : | 74468 |
Synonyms : |
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Application In Synthesis of [ 1757-72-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1757-72-8 ]
- 1
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[ 25365-71-3 ]
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[ 74-88-4 ]
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[ 1757-72-8 ]
Yield | Reaction Conditions | Operation in experiment |
67.3% |
|
Synthesis of other indole-3-carbaldehydes; Preparation of 1-methyl-2-phenyl-1 H-indole-3-carbaldehyde: To a solution of 2-phenyl-1 H-indole-3-carbaldehyde (7.41 g, 33.5 mmol) in DMF (50 ml) cooled to O0C was added in portions, sodium hydride (2.68 g, 67.0 mmol). After stirring for 30 minutes, iodomethane (4.18 ml, 67.0 mmol) was added and the reaction stirred for 30 minutes, then allowed to warm to room temperature and stirred overnight. Water (150 ml_) was added and the resulting solid was filtered, washed well with water and air dried to give a light green solid 1-methyl-2-phenyl-1 H-indole-3-carbaldehyde (5.30 g, 22.53 mmol, 67.3 % yield), MS (m/z) 236.3 (MH+). |
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With potassium hydroxide; In N,N-dimethyl-formamide; at 20℃; for 12h; |
Step 2: In a 500 ml flask provided with a cooling tube and a stirrer, 15.2 g of KOH, 38 g of iodomethane, 50 g of 2-phenyl 1H-Indole-3-carboxaldehyde, and 150 g of DMF (dimethylformamide) were placed and stirred at room temperature for 12 hours. The solvent was removed through distillation, thereby obtaining 1-methyl 2-phenyl 1H-indole-3-carboxaldehyde (molecular weight: 235.28 g/mol) and having a purity of 96% as measured by HPLC. (1H NMR: δ 9.76, s, 1H; δ 8.46, m, 1H; δ 7.59, m, 3H; δ 7.52, m, 2H; δ 7.42, m, 3H; δ 3.79, s, 3H) |
Reference:
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[7]Patent: US2021/151713,2021,A1 .Location in patent: Paragraph 0104