Alternatived Products of [ 1733-57-9 ]
Product Details of [ 1733-57-9 ]
CAS No. : | 1733-57-9 |
MDL No. : | MFCD00013912 |
Formula : |
C14H15OP
|
Boiling Point : |
- |
Linear Structure Formula : | (C6H5)2CH2CH3PO |
InChI Key : | AKTGKEBIBGSCLD-UHFFFAOYSA-N |
M.W : |
230.24
|
Pubchem ID : | 74423 |
Synonyms : |
|
Application In Synthesis of [ 1733-57-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1733-57-9 ]
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[ 1733-57-9 ]
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[ 607-01-2 ]
Yield | Reaction Conditions | Operation in experiment |
75%Spectr. |
With chloro-trimethyl-silane; magnesium; at 20℃; for 2h; |
General procedure: To a mixture of Mg powder (8 mmol, 4 mol equiv), Me3SiCl (6 mmol, 3 mol equiv), and DMI (8 mL) was added 2a (2 mmol), and the whole mixture was stirred for 2 h at room temperature. To the reaction mixture was added satd aq (NH4)2CO3, and the mixture was extracted with Et2O (10 mL 3). The combined organic layers were washed with satd aq NaCl, dried over Na2SO4, and concentrated under reduced pressure. The resultant was analyzed by 31P NMR to find that 1a and 2a were obtained in 97:3 ratio. The desired 1a was obtained in 96% yield after purification by silica gel column chromatography (hexane/AcOEt = 5:1) (Table 1, entry 1). |
95%Chromat. |
With [AlH3(triethylamine)]; In hexane; at 20℃; for 0.166667h;Inert atmosphere; Schlenk technique; |
General procedure: Triphenylphosphine oxide or sulfide (1 mmol), dry hexane (1 mL), and Ic (1 mmol) were added to a Schlenk tube under the atmosphere of nitrogen. The reaction was carried out at room temperature for 10 min and monitored by TLC. Upon completion of the process the reaction mixture was filtered by silica gel and washed several times with ethyl acetate. Ethyl acetate was evaporated and the residue purified by flash chromatography on silica gel with pure cyclohexane toafford the desired phosphine. The yield was determined by GC without additional purification. |
Reference:
[1]Tetrahedron Letters,1999,vol. 40,p. 5267 - 5270
[2]Tetrahedron Letters,1998,vol. 39,p. 4405 - 4406
[3]Tetrahedron Letters,1997,vol. 38,p. 5997 - 6000
[4]Tetrahedron Letters,2015,vol. 56,p. 918 - 920
[5]Russian Journal of General Chemistry,2015,vol. 85,p. 1156 - 1160
Zh. Obshch. Khim.,