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To a solution of 1 H-indole-7-carboxylic acid (20 g, 124 mmol, 1 .0 eq) in MeOH (700 ml) was added H2S04 (1.2 g, 12 mmol, 0.1 eq) and the mixture was stirred at reflux for 20 hrs. Then, MeOH was evaporated by rotavapor and the residue was dissolved in ethyl acetate. The organic phase was washed with saturated Na2C03, brine, dried over Na2S04 and filtered. The solvent was removed under reduced pressure to give intermediate 1 (16.3 g, 75percent yield) as a yellow solid.
1 g of indole-7-carboxylic acid was dissolved in 10 ml of methanol. 5 ml of trimethylsilyl diazomethane was added and the mixture was allowed to stand at room temperature for 30 minutes. 1 N acetic acid was added until the reaction solution became colorless, and the solvent was distilled off. The obtained substance was dissolved in distillation and adjusted to pH 8 and extracted with ethyl acetate. The ethyl acetate phase obtained was dried with anhydrous magnesium sulfate. This was dissolved in acetone and recrystallized, and the solvent was distilled off. As a result, 148.7 mg (yield: 13.7%) of a compound was obtained. NMR, mass spectrum and melting point of this compound were measured, and the compound 4 having the structure of the general formula 5 was confirmed.
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