成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 162504-75-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 162504-75-8
Chemical Structure| 162504-75-8
Structure of 162504-75-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 162504-75-8 ]

Related Doc. of [ 162504-75-8 ]

Alternatived Products of [ 162504-75-8 ]
Product Citations

Product Details of [ 162504-75-8 ]

CAS No. :162504-75-8 MDL No. :MFCD02179013
Formula : C14H25NO4 Boiling Point : No data available
Linear Structure Formula :- InChI Key :RWDYQFGCHAJYOJ-UHFFFAOYSA-N
M.W : 271.35 Pubchem ID :1502093
Synonyms :
Chemical Name :Methyl N-Boc-4-piperidinepropionate

Calculated chemistry of [ 162504-75-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 19
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.86
Num. rotatable bonds : 7
Num. H-bond acceptors : 4.0
Num. H-bond donors : 0.0
Molar Refractivity : 77.11
TPSA : 55.84 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.51 cm/s

Lipophilicity

Log Po/w (iLOGP) : 3.37
Log Po/w (XLOGP3) : 2.04
Log Po/w (WLOGP) : 2.21
Log Po/w (MLOGP) : 1.85
Log Po/w (SILICOS-IT) : 1.82
Consensus Log Po/w : 2.26

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.35
Solubility : 1.22 mg/ml ; 0.00451 mol/l
Class : Soluble
Log S (Ali) : -2.84
Solubility : 0.392 mg/ml ; 0.00144 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.16
Solubility : 1.88 mg/ml ; 0.00692 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 2.42

Safety of [ 162504-75-8 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 162504-75-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 162504-75-8 ]

[ 162504-75-8 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 194933-85-2 ]
  • [ 162504-75-8 ]
  • 2
  • [ 162504-75-8 ]
  • [ 154775-43-6 ]
YieldReaction ConditionsOperation in experiment
A solution of tert-butyl 4- (3-METHOXY-3-OXOPROPYL) PIPERIDINE-1-CARBOXYLATE (2.0 g, 7.37 mmol) in 8 ml of methanol was added a solution of LIOH monohydrate (0.46g, 11.0 mmol) in 2 ml of water. The resulting solution was stirred at rt for 16h and it was concentrated under vacuum. To the residue was added 0.35 ml of acetic acid and 0.1 ml of water. The mixture was poured into a solution of EtOAc and CH2CL2 (1 : 1). The organic layer was dried with NA2SO4, filtered through celite and concentrated. To give 1.6g of 3- [1- (tert-butoxycarbonyl) piperidin-4- yl] propanoic acid.
  • 3
  • [ 498-94-2 ]
  • [ 162504-75-8 ]
  • 4
  • [ 24424-99-5 ]
  • [ 162504-75-8 ]
  • 5
  • [ 84358-13-4 ]
  • [ 162504-75-8 ]
  • 6
  • [ 139290-70-3 ]
  • [ 162504-75-8 ]
  • 7
  • [ 137076-22-3 ]
  • [ 162504-75-8 ]
  • 8
  • [ 162504-75-8 ]
  • C19H30N3O9P [ No CAS ]
  • 9
  • [ 162504-75-8 ]
  • [ 1027851-27-9 ]
  • 10
  • [ 162504-75-8 ]
  • 4-[2-([(S)-2-Benzyloxycarbonyl-1-((S)-1-benzyloxycarbonyl-2-methyl-propylcarbamoyl)-ethylcarbamoyl]-methyl}-ethyl-carbamoyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]
  • 11
  • [ 162504-75-8 ]
  • 3-(4-piperidinyl)propionyl-N-ethylglycyl-aspartyl-valine trifluoroacetate [ No CAS ]
  • 12
  • [ 365998-55-6 ]
  • [ 162504-75-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium 10% on activated carbon; In methanol; under 2585.81 Torr; for 15h; To a solution of the compound of Step 2 (3.38 g, 12.6 mmol) in 50 ml of methanol was added lg of 10% Pd/C and the mixture was hydrogenated at 50 psi of H2 on Parr apparatus for 15 h. The mixture was filtered through celite and concentrated to afford 3. 11G of tert-butyl 4- (3- methoxy-3-oxopropyl) PIPERIDINE-1-CARBOXYLATE.
  • 13
  • [ 154775-43-6 ]
  • [ 74-88-4 ]
  • [ 162504-75-8 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 0 - 20℃; INTERMEDIATE 16 Step A: Iodomethane (556YL, 8. 93MMOL) was added dropwise to A cooled (0C) mixture of commercially available 3- [1- (tert-butoxycarbonyl) piperidin-4-yl] propanoic acid (2.09g, 8. 12mmol) and K2CO3 (2.81g, 20. 3MMOL) in 20ML of DMF. The reaction mixture was permitted to warm to rt and stir overnight. The reaction mixture was diluted with ether and washed four times with water, then once with brine. The ethereal layer was dried over anhydrous MgSO4, filtered, and concentrated. Purification by MPLC (silica, 40% ethyl acetate/hexanes) provided tert-butyl 4- (3-METHOXY-3-OXOPROPYL) PIPERIDINE-L- carboxylate.
With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20℃; Step A Iodomethane (556 muL, 8.93 mmol) was added dropwise to a cooled (0 C.) mixture of commercially available <strong>[154775-43-6]3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propanoic acid</strong> (2.09 g, 8.12 mmol) and K2CO3 (2.81 g, 20.3 mmol) in 20 mL of DMF. The reaction mixture was permitted to warm to rt and stir overnight. The reaction mixture was diluted with ether and washed four times with water, then once with brine. The ethereal layer was dried over anhydrous MgSO4, filtered, and concentrated. Purification by MPLC (silica, 40% ethyl acetate/hexanes) provided tert-butyl 4-(3-methoxy-3-oxopropyl)piperidine-1-carboxylate:
  • 14
  • [ 162504-75-8 ]
  • (+/-)-cis-N1-[3-[1-(tert-Butoxycarbonyl)piperidin-4-yl]propionyl]-N2-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
1) (+-)-cis-N1-[3-[1-(tert-Butoxycarbonyl)piperidin-4-yl]propionyl]-N2-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine was obtained from <strong>[162504-75-8]1-(tert-butoxycarbonyl)-4-[2-(methoxycarbonyl)ethyl]piperidine</strong> (J. Med. Chem., 1998, Vol. 41, p. 2492) in a similarmanner to the step 1) of Example 83. 1H-NMR (CDCl3) delta: 1.00-1.17(2H,m), 1.30-1.80(11H,m), 1.44(9H,s), 1.80-1.95(1H,m), 2.10-2.23(1H,m), 2.29(2H,t,J=7.8Hz), 2.50-2.70(2H,m), 3.90-4.18(3H,m), 4.23(1H,br.s), 6.05(1H,br,J=6.0Hz), 6.85(1H,d,J=2.0Hz), 7.22(1H,dd,J=8.8,1.8Hz), 7.37(1H,d,J=8.8Hz), 7.62(1H,d,J=1.8Hz), 7.89(1H,br.s), 9.59(1H,s). MS (ESI) m/z: 531(M+H)+.
YieldReaction ConditionsOperation in experiment
205 mg (97%) Step D: (3-(1-t-Butoxycarbonylpiperidin-4-yl)propanoic acid, methyl ester A solution of 200 mg (0.79 mmol) of (3-(1-t-butoxycarbonylpiperidin-4-yl)propanoic acid (from EXAMPLE 98, Step C) in 2 mL of 1:1 v/v MeOH/THF was treated with a 2 M trimethylsilyl-diazomethane solution in THF until a yellow color persisted. After stirring the mixture at rt for 1 h, the solution was concentrated and the residue purified by column chomatography on 15 g silica gel with a gradient of 0-25% acetone/hexanes (v/v) to give 205 mg (97%) of the title compound: 1H NMR (500 MHz) delta 1.11 (dq,J=4.3,8.3,2H). 1.38-1.44 (m, 1H), 1.46(s,9H), 1.59 (q, J=7.5, 2H), 1.65 (d, J=13.3, 2H), 2.35 (t, J=7.6, 2H), 2.62-2.73 (2H), 3.68 (s, 3H), 4.09 (bs, 2H).
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 162504-75-8 ]

Amides

Chemical Structure| 175213-46-4

[ 175213-46-4 ]

N-Boc-Piperidin-4-yl-acetic acid methyl ester

Similarity: 1.00

Chemical Structure| 135716-09-5

[ 135716-09-5 ]

tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Similarity: 0.98

Chemical Structure| 124443-68-1

[ 124443-68-1 ]

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

Similarity: 0.96

Chemical Structure| 154775-43-6

[ 154775-43-6 ]

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid

Similarity: 0.96

Chemical Structure| 872850-31-2

[ 872850-31-2 ]

2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid

Similarity: 0.96

Carboxylic Acids

Chemical Structure| 142247-38-9

[ 142247-38-9 ]

4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)butanoic acid

Similarity: 0.96

Chemical Structure| 154775-43-6

[ 154775-43-6 ]

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid

Similarity: 0.96

Chemical Structure| 872850-31-2

[ 872850-31-2 ]

2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid

Similarity: 0.96

Chemical Structure| 183483-09-2

[ 183483-09-2 ]

1-Boc-Piperidine-3-acetic acid

Similarity: 0.94

Chemical Structure| 189321-63-9

[ 189321-63-9 ]

1-Boc-4-Methylpiperidine-4-carboxylic acid

Similarity: 0.93

Related Parent Nucleus of
[ 162504-75-8 ]

Aliphatic Heterocycles

Chemical Structure| 175213-46-4

[ 175213-46-4 ]

N-Boc-Piperidin-4-yl-acetic acid methyl ester

Similarity: 1.00

Chemical Structure| 135716-09-5

[ 135716-09-5 ]

tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Similarity: 0.98

Chemical Structure| 124443-68-1

[ 124443-68-1 ]

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

Similarity: 0.96

Chemical Structure| 154775-43-6

[ 154775-43-6 ]

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid

Similarity: 0.96

Chemical Structure| 872850-31-2

[ 872850-31-2 ]

2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid

Similarity: 0.96

Piperidines

Chemical Structure| 175213-46-4

[ 175213-46-4 ]

N-Boc-Piperidin-4-yl-acetic acid methyl ester

Similarity: 1.00

Chemical Structure| 135716-09-5

[ 135716-09-5 ]

tert-Butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate

Similarity: 0.98

Chemical Structure| 124443-68-1

[ 124443-68-1 ]

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

Similarity: 0.96

Chemical Structure| 154775-43-6

[ 154775-43-6 ]

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid

Similarity: 0.96

Chemical Structure| 872850-31-2

[ 872850-31-2 ]

2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid

Similarity: 0.96

; ;