* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In tetrahydrofuran; water; at 85 - 90℃; for 5h;
To a two-necked flask was added 1.1 to 1.2 equivalents of thieno [3,2-b] thiophene, 1 g (226 mol) of 2-bromo-4- (trifluoromethyl) (PPh3), 3 equivalents of Na2CO3 and 0.4 equivalents of Aliguat 336 were added to a solution of 80 ml of THF and 50 ml of H20, and the mixture was stirred at 85 to 90 DEG C for 5 hours under a nitrogen atmosphere. After the stirring, the organic layer containing the product was separated using a glass filter, washed with hexane as an organic substance, and washed and purified with distilled water as an inorganic substance to obtain a ligand by a Suzuki coupling reaction