成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 151169-75-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 151169-75-4
Chemical Structure| 151169-75-4
Structure of 151169-75-4 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 151169-75-4 ]

Related Doc. of [ 151169-75-4 ]

Alternatived Products of [ 151169-75-4 ]
Product Citations

Product Details of [ 151169-75-4 ]

CAS No. :151169-75-4 MDL No. :MFCD01074646
Formula : C6H5BCl2O2 Boiling Point : No data available
Linear Structure Formula :- InChI Key :JKIGHOARKAIPJI-UHFFFAOYSA-N
M.W : 190.82 Pubchem ID :2734330
Synonyms :

Calculated chemistry of [ 151169-75-4 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 2.0
Num. H-bond donors : 2.0
Molar Refractivity : 46.29
TPSA : 40.46 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.99 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : 2.08
Log Po/w (WLOGP) : 0.67
Log Po/w (MLOGP) : 1.48
Log Po/w (SILICOS-IT) : 0.57
Consensus Log Po/w : 0.96

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.67
Solubility : 0.407 mg/ml ; 0.00213 mol/l
Class : Soluble
Log S (Ali) : -2.56
Solubility : 0.526 mg/ml ; 0.00276 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.52
Solubility : 0.572 mg/ml ; 0.003 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.86

Safety of [ 151169-75-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 151169-75-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 151169-75-4 ]

[ 151169-75-4 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 30913-86-1 ]
  • [ 151169-75-4 ]
  • 4-(3',4'-dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
sodium carbonate; tetrakis(triphenylphosphine)palladium (0); In toluene; Step (a) Preparation of 4-(3',4'-Dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester In a manner similar to Example 12, Step (b), (3,4-dichloro-phenyl)boronic acid (1.0569 g, 0.005539 mol) was allowed to react with 4-(4-bromo-phenyl)-4-oxo-butyric acid, methyl ester (1.3636 g, 0.005019 mol) in the presence of tetrakis(triphenylphosphine)palladium(0) (0.1054 g, 0.0000912 mol) and 2.0 M aqueous sodium carbonate (5.5 mL, 0.011 mol) in toluene (11 mL) to give, after chromatography on silica gel (270 g, 230-400 mesh), eluding with hexanes-acetone (7:1) 1.432 g of 4-(3',4'-dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester as a white solid; mp 120-121 C.
  • 2
  • [ 2401-21-0 ]
  • [ 151169-75-4 ]
  • [ 41464-43-1 ]
  • 3
  • [ 53547-61-8 ]
  • [ 151169-75-4 ]
  • [ 2039-83-0 ]
  • [ 32598-13-3 ]
  • 4
  • [ 1000341-27-4 ]
  • [ 151169-75-4 ]
  • (3-(3,4-dichlorophenyl)-6-(trifluoromethyl)-1H-indazole) [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium acetate; In 1,4-dioxane; water; at 100.0℃; for 16.0h;Inert atmosphere; (1207) To the iodo compound 389 (30 mg, 0.16 mmol), in dioxanewater (31 ml), 3,4-dichloro phenyl boronic acid (37 mg, 0.19 mmol), sodium acetate (62 mg, 0.76 mmol) and PdCl2(dppf) (23 mg, 0.03 mmol) were added. Then the reaction mixture was heated to 100 C. for 16 h. Then reaction mixture was cooled and diluted with ethyl acetate. Organic layer was separated and washed with water, brine and dried. Crude residue was column chromatographed to yield 390 (3-(3,4-dichlorophenyl)-6-(trifluoromethyl)-1H-indazole) in 65% yield. 1H NMR (CDCl3): 10.41 (br s, 1H), 8.1 (m, 2H), 7.68-7.72 (m, 2H), 7.60 (m, 1H), 7.53 (d, 1H). Mass spectrum (ESI+): m/z=331 [M+1].
  • 5
  • [ 865156-68-9 ]
  • [ 151169-75-4 ]
  • 6-(3,4-dichlorophenyl)imidazo[1,2-a]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
520 mg With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In tetrahydrofuran; water; at 100℃; for 1h;Inert atmosphere; Microwave irradiation; The compound of Reference Example 4 (600 mg), 3,4-dichlorophenylboronic acid (635 mg), tetrakis (triphenylphosphine) palladium (175 mg) and sodium carbonate(803 mg) in tetrahydrofuran / water mixed solution (10.1 mL / 5 mL)Were stirred at 100 C. for 1 hour under a nitrogen atmosphere using a microwave reactor. After cooling to room temperature, water was added and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (n-hexane / ethyl acetate) to give the title compound (520 mg) as a solid.
  • 6
  • [ 52133-67-2 ]
  • [ 151169-75-4 ]
  • ethyl 2-(3,4-dichlorophenyl)-1H-pyrrole-3-carboxylate [ No CAS ]
  • 7
  • [ 21193-80-6 ]
  • [ 151169-75-4 ]
  • 4-amino-5-(3,4-dichlorophenyl)-N7-(β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
29% With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; at 100℃;Inert atmosphere; General procedure: 31 (1 eq.), boronic acid (1.5 eq.) or pinacol ester [for compound14 (1.5 eq.)], Na2CO3 (9 eq.), Pd(OAc)2 (0.05 eq.) and TPPTS (0.15 eq.)were added to a 10mL round-bottom flask, equipped with a stir bar.Next, the flask was evacuated and refilled with argon. This procedure was repeated three times in total. Next, degassed MeCN(2 mL/mmol SM) and H2O (4 mL/mmol SM) were added to the solids under argon. After 5 min of stirring, the mixture was heatedto 100 C in a pre-heated oil bath. When the starting material was fully consumed (usually 1e3 h), the mixture was cooled to ambient temperature, and neutralized (pH ~ 7) with 0.5M aq. HCl. Themixture was evaporated till dryness, resuspended in MeOH and evaporated (three times). Next, the mixture was adsorbed onto Celite (fromMeOH) and eluted over a short silica pad (~5 cm) with 20% MeOH/DCM. The liquid was evaporated in vacuo and purified by column chromatography.
  • 8
  • [ 1445-39-2 ]
  • [ 151169-75-4 ]
  • C10H7Cl2N3 [ No CAS ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 151169-75-4 ]

Organoboron

Chemical Structure| 1679-18-1

[ 1679-18-1 ]

(4-Chlorophenyl)boronic acid

Similarity: 0.95

Chemical Structure| 67492-50-6

[ 67492-50-6 ]

3,5-Dichlorophenylboronic acid

Similarity: 0.93

Chemical Structure| 63503-60-6

[ 63503-60-6 ]

3-Chlorophenylboronic acid

Similarity: 0.93

Chemical Structure| 862248-93-9

[ 862248-93-9 ]

(3,4,5-Trichlorophenyl)boronic acid

Similarity: 0.91

Chemical Structure| 3900-89-8

[ 3900-89-8 ]

(2-Chlorophenyl)boronic acid

Similarity: 0.87

Aryls

Chemical Structure| 1679-18-1

[ 1679-18-1 ]

(4-Chlorophenyl)boronic acid

Similarity: 0.95

Chemical Structure| 67492-50-6

[ 67492-50-6 ]

3,5-Dichlorophenylboronic acid

Similarity: 0.93

Chemical Structure| 63503-60-6

[ 63503-60-6 ]

3-Chlorophenylboronic acid

Similarity: 0.93

Chemical Structure| 862248-93-9

[ 862248-93-9 ]

(3,4,5-Trichlorophenyl)boronic acid

Similarity: 0.91

Chemical Structure| 3900-89-8

[ 3900-89-8 ]

(2-Chlorophenyl)boronic acid

Similarity: 0.87

Chlorides

Chemical Structure| 1679-18-1

[ 1679-18-1 ]

(4-Chlorophenyl)boronic acid

Similarity: 0.95

Chemical Structure| 67492-50-6

[ 67492-50-6 ]

3,5-Dichlorophenylboronic acid

Similarity: 0.93

Chemical Structure| 63503-60-6

[ 63503-60-6 ]

3-Chlorophenylboronic acid

Similarity: 0.93

Chemical Structure| 862248-93-9

[ 862248-93-9 ]

(3,4,5-Trichlorophenyl)boronic acid

Similarity: 0.91

Chemical Structure| 3900-89-8

[ 3900-89-8 ]

(2-Chlorophenyl)boronic acid

Similarity: 0.87

; ;