[ CAS No. 1493-27-2 ] {[proInfo.proName]}

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Quality Control of [ 1493-27-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1493-27-2 ]

SDS Specification

Alternatived Products of [ 1493-27-2 ]

Product Details of [ 1493-27-2 ]

CAS No. :	1493-27-2	MDL No. :	MFCD00007048
Formula :	C₆H₄FNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	PWKNBLFSJAVFAB-UHFFFAOYSA-N
M.W :	141.10	Pubchem ID :	73895
Synonyms :

Calculated chemistry of [ 1493-27-2 ] Expand+

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	35.22
TPSA :	45.82 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.96 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.28
Log Po/w (XLOGP3) :	1.69
Log Po/w (WLOGP) :	2.15
Log Po/w (MLOGP) :	2.1
Log Po/w (SILICOS-IT) :	0.11
Consensus Log Po/w :	1.47

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.16
Solubility :	0.982 mg/ml ; 0.00696 mol/l
Class :	Soluble
Log S (Ali) :	-2.27
Solubility :	0.763 mg/ml ; 0.00541 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.03
Solubility :	1.31 mg/ml ; 0.00931 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.57

Safety of [ 1493-27-2 ]

Signal Word:	Danger	Class:	6.1
Precautionary Statements:	P260-P264-P270-P271-P273-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P314-P391-P405-P501	UN#:	2810
Hazard Statements:	H302+H332-H311-H372-H411	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 1493-27-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1493-27-2 ]
Downstream synthetic route of [ 1493-27-2 ]

[ 1493-27-2 ] Synthesis Path-Upstream 1~1

1
[ 141-43-5 ]
[ 1493-27-2 ]
[ 4926-55-0 ]

Yield	Reaction Conditions	Operation in experiment
82.9%	With potassium carbonate In ethanolReflux	2-fluoronitrobenzene (0.92 g, 6.53 mmol) and ethanolamine (1.19 g, 19.59 mmol) were dissolved in 20 mL ethanol, potassium carbonate (1.08 g, 7.83 mmol) was added and stirred under reflux for 5-6 hours, after the reaction solution was cooled, filtered, the filtrate was concentrated under reduced pressure, to obtain an orange solid, and 20 mL saturated brine was added, extracted with ethyl acetate (3×40 mL), the organic phases were combined, washed with a saturated brine, dried on anhydrous sodium sulfate, rotary evaporated, purified by silica gel column chromatography to obtain 2-nitro-N-(2-hydroxyethyl)aniline (0.98 g, yield 82.9percent).

Reference： [1] Tetrahedron Letters, 2010, vol. 51, # 17, p. 2362 - 2365
[2] Tetrahedron, 1998, vol. 54, # 18, p. 4647 - 4654
[3] Green Chemistry, 2013, vol. 15, # 3, p. 798 - 810
[4] Chemical Communications, 2013, vol. 49, # 85, p. 9935 - 9937
[5] Patent: US2017/114085, 2017, A1, . Location in patent: Paragraph 0053
[6] Tetrahedron, 1998, vol. 54, # 18, p. 4647 - 4654
[7] Bulletin de la Societe Chimique de France, 1956, p. 311,315
[8] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 21, p. 4790 - 4793
[9] Tetrahedron Letters, 2006, vol. 47, # 38, p. 6899 - 6902
[10] Journal of Physical Organic Chemistry, 2011, vol. 24, # 8, p. 714 - 719

[ 1493-27-2 ] Synthesis Path-Downstream 1~11

1
[ 106-47-8 ]
[ 1493-27-2 ]
[ 23008-56-2 ]

Yield	Reaction Conditions	Operation in experiment
93.9%	With triethylamine; at 105 - 115℃; for 12h;	107.6 g of triethylamine, 150 g of o-fluoronitrobenzene,P-chloroaniline (203.4 g), the system was heated to 105-115 C for 12 hours,HPLC showed that the reaction was complete,After cooling to 20-30 C,The filter cake was washed with 150 mL of methanol,Drying, get 248g products. Purity 99.8%Yield 93.9%.
72.3%		General procedure: To the suspension of NaH (75 mol) in DMF (60 mL), substitutedamines (50 mmol) was added at 0 C. The mixture was stirred for30 min at the same temperature, and then 2-fluoronitrobenzene(60 mmol) diluted in DMF (30 mL) was added slowly. The mixturewas warmed to room temperature and stirred for 16 h. The reactionmixture was carefully poured into stirring saturated NH4Cl(500 mL), then filtered. The filter cake was washed with water,and recrystallized from methanol to afford corresponding N-aryl-2-nitroanilines 15a-15n.6.2.8 N-(4-chlorophenyl)-2-nitroaniline (15h) Orange solid; Yield: 72.3%; M.p.: 135.1-137.0 C; 1H NMR (400 MHz, DMSO-d6) delta 9.31 (s, 1H), 8.12 (d, J = 8.0, 1H), 7.53(t, J = 7.6 Hz, 1H), 7.44 (d, J = 8.8 Hz, 2H), 7.34 (d, J = 8.8 Hz, 2H), 7.22 (d, J = 8.4 Hz, 1H), 6.93 (t, J = 7.6 Hz, 1H); MS (ESI) m/z (%): 247.2 [M-H]-.
72%	With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 120 - 125℃; for 8h;Inert atmosphere;	In the reaction flask,Put 87 g of o-fluoronitrobenzeneAnd 200 grams of DMAC,94 grams of diisopropylethylamine was added with stirring,After warming to 120 degrees under nitrogen.71 grams of p-chloroaniline was dissolved in 100 grams of DMAC to prepare a solution,After that, the solution was slowly added dropwise to the above reaction system.Dropping temperature will rise during the process,The reaction temperature should be controlled by cooling within 125 degrees.The reaction was continued at 120 to 125 degrees for 8 hours,HPLC monitors the progress of the reaction.When the content of chloroaniline is not declining,At the end of the reaction, about 11% of the chloroaniline remained.Cool to 60 degrees.After the same way with the first embodiment,Finally, 100 g of the condensate intermediate N- (4-chlorophenyl) -2-nitro-1-aniline,Yield 72%HPLC purity> 98%.

52%	With potassium fluoride; potassium carbonate; In dichloromethane; at 220℃; for 0.466667h;Microwave irradiation;	N-(4-chlorophenyl)-2-nitrobenzenamineA mixture of 2-fluoronitrobenzene (3.5 g, 24.8 mmol), 4-chlorobenzenamine (3.05 g, 24.0 mmol), K2C03 (3.45 g, 25.0 mmol) and KF (1.5 g, 25.8 mmol) was heated at 220 C for 28 min under microwave condition. The solid was dissolved in DCM (150 mL), washed with water (50 mL x 3), dried over Na2S04. The solvent was evaporated in vacuo, and then the mixture was purified by Combi-flash (PE : EA = 20 : 1) to give N-(4-chlorophenyl)-2-nitrobenzenamine (3.2 g, 52%) as a scarlet solid. 1H NMR (300 MHz, CD3OD): delta 6.82-6.87 (m, 1H), 7.27-7.31 (m, 2H), 7.41-7.45 (m, 3H), 7.70-7.73 (m, 1H), 8.15-8.18 (m, 1H).
	In pyridine; water;	Referential Example 16 2-(4-Chlorophenylamino)nitrobenzene 2-Fluoronitrobenzene (3.0 g) and 4-chloroaniline (2.5 g) were dissolved in pyridine (30 ml) and stirred at 80 C. for 18 hours. The resultant solution was allowed to cool, and thereafter, water (100 ml) was added thereto and the mixture was extracted with ethyl acetate (50 ml*3). The organic layer was washed with water and saturated brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the residue was re-crystallized from ethyl acetate-hexane, to thereby yield the target compound (2.5 g) as pale-brown crystals. 1H-NMR(270 MHz, CDCl3) delta: 9.40 (1H, brs), 8.20 (1H, dd, J=8.58 Hz), 7.37 (2H, d, J=8.90 Hz), 7.35~7.39 (2H, m), 7.21 (2H, d, J=8.90 Hz), 7.15~7.19 (2H, m), 6.80 (1H, t, J=7.26 Hz).
	With potassium fluoride; at 180℃; for 10h;	A mixture of 2-fluoro-nitrobenzene (33.7 g), 4-chloroanilinc (61.0 g) and anhydrous potassium fluoride (13.9 g) was stirred at 180 C for 10 h. After being cooled to rt, 3 M HC1 was added and the mixture was stirred at 100 C for 30 min. Then cooled to rt, filtered by suction, washed with water to give a brown solid. The solid was dissolved in CH2CI2 and filtered through a thin pad of silica gel, washed with CH2CI2. The filtrate was concentrated to dryness, and the residue was recrystallized with 95% ethanol to give 57.0 g of orange solid.

Reference： [1]Patent: CN106916069,2017,A .Location in patent: Paragraph 0016; 0017; 0018; 0019; 0020; 0021; 0022-0024
[2]Organic Process Research and Development,2016,vol. 20,p. 452 - 464
[3]Molecules,2012,vol. 17,p. 4545 - 4559
[4]Synlett,2003,p. 564 - 566
[5]Bioorganic and Medicinal Chemistry,2017,vol. 25,p. 4475 - 4486
[6]Patent: CN107445845,2017,A .Location in patent: Paragraph 0033; 0034; 0035; 0036; 0037; 0038; 0039-0045
[7]Synthesis,1980,p. 215
[8]Chinese Journal of Chemistry,2013,vol. 31,p. 1473 - 1482
[9]Patent: WO2012/151512,2012,A2 .Location in patent: Page/Page column 103
[10]ACS Medicinal Chemistry Letters,2016,vol. 7,p. 145 - 150
[11]Liebigs Annales,1995,p. 1275 - 1282
[12]Patent: US6403607,2002,B1
[13]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3138 - 3141
[14]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 5443 - 5448
[15]Patent: WO2012/3190,2012,A1 .Location in patent: Page/Page column 44-45
[16]Chinese Chemical Letters,2012,vol. 23,p. 707 - 710
[17]Journal of Medicinal Chemistry,2012,vol. 55,p. 8409 - 8417,9
[18]European Journal of Organic Chemistry,2019,vol. 2019,p. 5161 - 5164

2
[ 114676-59-4 ]
[ 1493-27-2 ]
[ 214143-74-5 ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 1247 - 1254

3
[ 88675-24-5 ]
[ 1493-27-2 ]
[ 767305-19-1 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 180℃; for 0.333333h;Microwave irradiation;	Step A. (+/-)-N-(2-Nitrophenyl)tetrahvdrofuran-3 -amineA solution of N, jV-diisopropylethylamine (3.20 mL, 18.4mmol), l-fluoro-2- nitrobenzene (0.484 mL, 4.59 mmol), and (+/-)-tetrahydrofuran-3 -amine (400 mg, 4.59 mmol) in rc-butanol (10 mL) was heated to 180 0C in a microwave reactor. After 20 min, the reaction was allowed to cool to ambient temperature and concentrated. Purification by silica gel chromatography, eluting with a gradient of hexane: EtOAc - 100:0 to 0:100, gave the title compound. MS: mlz = 209 (M + 1).
	With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 180℃; for 0.333333h;microwave reactor;	A solution of N, N-diisopropylethylamine (3.20 mL, 18.4mmol), l-fluoro-2-nitrobenzene (0.484 mL, 4.59 mmol), and (+)-tetrahydrofuran-3 -amine (400 nig, 4.59 mmol) in 7z-butanol (10 mL) was heated to 180 0C in a microwave reactor. After 20 min, the reaction was allowed to cool to ambient temperature and concentrated. Purification by silica gel chromatography, eluting with a gradient of hexane:EtOAc - 100:0 to 0:100, gave the title compound. MS: mlz = 209 (M + 1).

Reference： [1]Patent: WO2008/130512,2008,A1 .Location in patent: Page/Page column 70
[2]Patent: WO2006/31610,2006,A2 .Location in patent: Page/Page column 67

4
[ 35418-07-6 ]
[ 1493-27-2 ]
2-[[4-[2-(methoxycarbonyl)ethyl]phenyl]amino]-aniline [ No CAS ]
2-[[4-[2-(methoxycarbonyl)-ethyl]phenyl]-amino]-nitrobenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		(3) 2-[[4-[2-(methoxycarbonyl)ethyl]phenyl]amino]-aniline The starting material 2-[[4-[2-(methoxycarbonyl)-ethyl]phenyl]-amino]-nitrobenzene (melting point: 68-70 C.) is obtained by reacting 2-fluoro-nitrobenzene with <strong>[35418-07-6]methyl 3-(4-aminophenyl)propionate</strong>. Rf value: 0.25 (Silica gel; methylene chloride/ethyl acetate=100:1)

Reference： [1]Patent: US5681841,1997,A

5
[ 1493-27-2 ]
[ 121148-00-3 ]
[ 922164-28-1 ]

Yield	Reaction Conditions	Operation in experiment
87%	In N,N-dimethyl-formamide; at 100℃; for 2.5h;Microwave irradiation;	Example 114: Preparation of Compound 114.Me Step 1.; Aminoproline (5g, 17.8 mmol) and fluoronitrobenzene (1.9mL, 17.8 mmol) were taken up in DMF (5mL) and placed in a sealed tube which was then heated via microwave to 1000C for 2.5h. The reaction was cooled and ethyl acetate and brine were added. The organic layer was separated, dried, concentrated and purified via flash chromatography to provide the nitrobenzyl compound (5.63g, 87percent). The nitrobenzyl species (2.86g, 7.85 mmol) was taken up in ethanol (70 mL). Palladium on carbon (10percent) was added and the flask charged with hydrogen gas. The mixture was stirred at room temp for Ih and then filtered through a fritted funnel. The filtrate was concentrated and purified via flash chromatography to provide the diamine (2g, 76percent).

Reference： [1]Patent: WO2007/11658,2007,A1 .Location in patent: Page/Page column 150

6
[ 443-86-7 ]
[ 1493-27-2 ]
[ 1033224-70-2 ]

Yield	Reaction Conditions	Operation in experiment
		Step 1 : <strong>[443-86-7]3-Fluoro-2-methylaniline</strong> (1.7 ml, 15 mmol) was dissolved in DMF (10 mL) and sodium hydride (0.58 g, 15 mmol) was added and the mixture was stirred for 30 minutes. 2-Fluoronitrobenzene (1.05 mL, 10 mmol) was added and the mixture was stirred for 16 hours. The mixture was quenched with saturated NH4CI and diluted with ether. The mixture was washed with water, brine, dried over anhydrous magnesium sulfate, and concentrated. The crude product was purified via lsco chromatography (Redisep, silica, gradient 5-30percent ethyl acetate in hexane) to afford 1.2 g (3-fluoro-2-methyl-phenyl)-(2-nitro- phenyl)-amine that was carried on directly to the next step.

Reference： [1]Patent: WO2008/73459,2008,A1 .Location in patent: Page/Page column 94

7
[ 22300-52-3 ]
[ 1493-27-2 ]
[ 1192847-33-8 ]

Reference： [1]Organic Letters,2009,vol. 11,p. 5026 - 5028
[2]Organic Process Research and Development,2019,vol. 23,p. 234 - 243
[3]Organic Process Research and Development,2019,vol. 23,p. 234 - 243

8
[ 625-05-8 ]
[ 1493-27-2 ]
[ 1407835-28-2 ]

Yield	Reaction Conditions	Operation in experiment
79%	With potassium carbonate; In ethanol;Reflux;	3-methyl-3-(2-nitrophenylamino)butanoic acid (Step 1). A round bottomed flask was charged with <strong>[625-05-8]3-amino-3-methylbutanoic acid</strong> (1.452 g, 12.39 mmol), potassium carbonate (2.57 g, 18.59 mmol), and a stirbar. EtOH (20 mL, 0.5 M) was added, followed by l-fluoro-2- nitrobenzene (2.84 ml, 15.49 mmol), and the solution was stirred at reflux overnight. The mixture was cooled, concentrated with celite, and purified by silica gel chromatography (eluting with methylene chloride/methanol/ammonium hydroxide) to yield 3-methyl-3-(2- nitrophenylamino)butanoic acid as a red solid (2.32 g, 9.73 mmol, 79percent).

Reference： [1]Patent: WO2012/151512,2012,A2 .Location in patent: Page/Page column 180

9
[ 1493-27-2 ]
[ 2622-63-1 ]

Reference： [1]Journal of Organic Chemistry,2014,vol. 79,p. 4727 - 4734
[2]Chemical Communications,2019,vol. 55,p. 2066 - 2069

10
[ 76205-19-1 ]
[ 1493-27-2 ]
1-(4-chlorophenyl)-3-(2-nitrophenoxy)-1H-pyrazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79.03%	With potassium carbonate; In N,N-dimethyl-formamide; for 6h;Reflux;	1-(4-Chlorophenyl)-3-hydroxy-1H-pyrazole (5.85 g, 30.00 mmol) was added to the reaction flask in that order.2-fluoronitrobenzene (4.23 g, 30.00 mmol), DMF (60 mL) and potassium carbonate (4.55 g, 33.00 mmol),The reaction solution was heated to reflux. After refluxing for 6 hours, the reaction mixture was cooled to room temperature, and water (100 ml) was evaporated.The organic layer was washed with brine (50 ml) and dried over anhydrous magnesium sulfate.Was concentrated under reduced pressure, the residue was purified by column chromatography (as eluent PE: EA = 20: 1), to give a white solid 7.5 g, yield 79.03percent.

Reference： [1]Patent: CN108707114,2018,A .Location in patent: Paragraph 0064; 0066-0068

11
[ 1493-27-2 ]
[ 162167-97-7 ]
tert-butyl 3-(((4-(methoxycarbonyl)-2-nitrophenyl)amino)methyl)piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With potassium carbonate; In N,N-dimethyl-formamide; at 20℃; for 4h;	To a stirred solution of l-fluoro-2-nitrobenzene (0.1 g, 0.52 mmol) in N,N-dimethyformamide (5 mL) at room temperature was added potassium carbonate (0.14 g, 1.04 mmol) and tert-butyl 3-(aminomethyl)piperidine-l-carboxylate (0.13 g, 0.62 mmol), the reaction mixture was stirred at room temperature for 4 h. The reaction mixture was quenched with water (10 mL) and extracted with ethyl acetate (3 x 20 mL). The combined organic layer was washed with water (25 mL), brine (25 mL), dried over anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by flash column chromatography by using combiflash purifier with 20 % ethyl acetate in hexane as eluent to give the title compound as yellow solid m/z = 392.1 [M + H] ; Yield (0.15 g, 73 %).

Reference： [1]Patent: WO2019/204505,2019,A2 .Location in patent: Paragraph 0387

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P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 1493-27-2 ] {[proInfo.proName]}

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[ 1493-27-2 ] Synthesis Path-Upstream 1~1

[ 1493-27-2 ] Synthesis Path-Downstream 1~11

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Fluorinated Building Blocks

Aryls

Nitroes

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[ 1493-27-2 ]

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