成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 14924-53-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 14924-53-9
Chemical Structure| 14924-53-9
Structure of 14924-53-9 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 14924-53-9 ]

Related Doc. of [ 14924-53-9 ]

Alternatived Products of [ 14924-53-9 ]
Product Citations

Product Details of [ 14924-53-9 ]

CAS No. :14924-53-9 MDL No. :MFCD00001321
Formula : C7H12O2 Boiling Point : -
Linear Structure Formula :- InChI Key :SMVBADCAMQOTOV-UHFFFAOYSA-N
M.W : 128.17 Pubchem ID :84700
Synonyms :

Calculated chemistry of [ 14924-53-9 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 9
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.86
Num. rotatable bonds : 3
Num. H-bond acceptors : 2.0
Num. H-bond donors : 0.0
Molar Refractivity : 34.93
TPSA : 26.3 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.03 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.26
Log Po/w (XLOGP3) : 1.48
Log Po/w (WLOGP) : 1.35
Log Po/w (MLOGP) : 1.23
Log Po/w (SILICOS-IT) : 1.53
Consensus Log Po/w : 1.57

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.37
Solubility : 5.48 mg/ml ; 0.0428 mol/l
Class : Very soluble
Log S (Ali) : -1.64
Solubility : 2.94 mg/ml ; 0.0229 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.2
Solubility : 8.09 mg/ml ; 0.0631 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.57

Safety of [ 14924-53-9 ]

Signal Word:Danger Class:3
Precautionary Statements:P210-P403+P235 UN#:3272
Hazard Statements:H225 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 14924-53-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14924-53-9 ]

[ 14924-53-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 14924-53-9 ]
  • [ 74-88-4 ]
  • [ 65338-28-5 ]
YieldReaction ConditionsOperation in experiment
With lithium diisopropyl amide; In tetrahydrofuran; 1-Methyl-cyclobutanecarboxylic acid ethyl ester 1 was prepared from ethyl cyclobutanecarboxylate by the method described in J. Am. Chem. Soc, Vol. 103 No.2 1981 436-442.
With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 20℃; Step A; Ethyl 1-Methylcyclobutanecarboxylic Acid; To a solution of ethyl cyclobutanecarboxylate (1.0 g, 7.8 mmol) and methyl iodide (2.4 mL, 39 mmol) in 20 mL of anhydrous tetrahydrofuran at -78C was added potassium hexamethyldisilazide (0.5 M in toluene, 23 mL, 12 mmol), and the reaction was allowed to warm to room temperature overnight. After quenching with saturated ammonium chloride (10 mL), the resulting mixture was partitioned between water (100 mL) and ethyl acetate (100 mL). The organic layer was separated, washed with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated to dryness to give the title compound, which was used without further purification. *H NMR (500 MHz, CD3OD): delta 4.12 (q,2H), 2.5-1.8 (m, 6H), 1.48 (s, 3H), 1.25 (t, 3H).
With lithium diisopropyl amide; In tetrahydrofuran; 1-Methyl-cyclobutanecarboxylic acid ethyl ester 1 was prepared from ethyl cyclobutanecarboxylate by the method described in J. Am. Chem. Soc, Vol. 103 No.2 1981 436-442.1-Methyl-cyclobutanecarboxylic acid ethyl ester 1 (1eq) was stirred under a nitrogen atmosphere at O0C in anhydrous THF. To this solution was added portionwise lithium aluminium hydride (1.5eq) and the suspension was stirred at room temperature for 3 hours. The reaction mixture was cooled on ice, treated with 1 M HCI (aq) and stirred at O0C 20 minutes. The solution was passed through a pad of celite and the filtrate extracted into diethyl ether. The organic phases were dried over MgSO4, filtered and concentrated in vacuo to give (i-methyl-cyclobutyl)-methanol, 2.Pyridinium chlorochromate (1.25eq) and the same weight of celite were taken up as a suspension in anhydrous dichloromethane. To this was added dropwise a solution of compound 2 (1eq) in anhydrous dichloromethane and the resulting heterogeneous mixture was stirred at room temperature for 3 hours. The reaction mixture was passed through a pad of silica, eluting with 19:1 isohexanes: ethyl acetate to give 1- methylcyclobutanecarboxaldehyde, 3.Compound 3 (1eq) was dissolved with stirring in anhydrous dichloromethane, and to this was added Boc-phosphoglycine trimethyl ester (0.5eq) and 1 ,8- EPO <DP n="120"/>diazabicyclo[5.4.0]undec-7-ene (1.2eq). The resulting solution was stirred at ambient temperature under nitrogen overnight. The reaction mixture was partitioned between dichloromethane and successively 1 M HCI (aq), sat. NaHCO3 (aq) and sat. NaCI (aq). The organic layer was dried over MgSO4, filtered and concentrated in vacuo. The resulting oil was purified by flash column chromatography, eluting with 1%methanol in dichloromethane to give 2-tert-butoxycarbonylamino-3-(1-methyl-cyclobutyl)-acrylic acid methyl ester, 4.Compound 4 was dissolved in anhydrous methanol and degassed with nitrogen. (+)- 1 ,2-bis (2S,5S)-diethylphosphonolanbenzene (cyclooctadiene)rhodium (I) triflate was added and degassing was continued for a further 10 minutes. The reaction was shaken under a hydrogen atmosphere (4 bar) for 48 hours. The solution was concentrated, in vacuo and purified by flash chromatography, eluting with dichloromethane, to give 2S- tert-butoxycarbonylamino-3-(1-methyl-cyclobutyl)-propionic acid methyl ester, 5.HPLC retention time 5.88min (monitored at 215 and 254 nm) HPLC using Synergy Max RP 80 mum 50x4.6mm column, 10?90% 6 min gradient of solution B (solution A = 0.1% TFA in water and solution B = 10% A in acetonitrile) at flow rate of 2ml/min.MS [M+H]+ 272.08 (20%) [M-Boc+H]+ 172.06 (100%)Electrospray ionisation, eluting with acetonitrile / ammonium formate buffer.1H NMR (400 MHz, CDCI35 4.83.79 (1 H, m) 4.33-4.27 (1 H, m) 3.71 (3H, s) 1.98-1.62 (8H, m) 1.42 (9H, s) 1.22 (3H, s)
With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20℃; Formation of ethyl 1-methylcyclobutanecarboxylate (111a)A solution of ethyl cyclobutanecarboxylate (20.0 g, 156.0 mmol) in THF (160 mL) was added dropwise to a cold (-78 C) solution of LDA (164 mmol of 2M solution) in THF (40 mL). The solution was warmed to 0 C and then cooled again to -40 C before the addition of iodomethane (10.2 mL, 163.8 mmol). The solution was slowly warmed to room temperature and stirred overnight. The reaction was quenched with an aqueous saturated solution of ammonium chloride and ether was added. The layers were separated and the aqueous layer was washed with ether. The combined organic layers were washed with IN HC1 then dried over MgS04. The product was purified by distillation: 1H NMR (400 MHz, MeOD) delta 4.20 - 4.05 (m, 2H), 2.57 - 2.33 (m, 2H), 2.08 - 1.94 (m, 1H), 1.94 - 1.77 (m, 3H), 1.40 (s, 3H), 1.27 (tt, J = 7.1, 1.5 Hz, 3H).
Formation of ethyl 1-methylcyclobutanecarboxylate (22a) A solution of ethyl cyclobutanecarboxylate (20.0 g, 156.0 mmol) in THF (160 mL) was added dropwise to a cold (-78 C) solution of LDA (164 mmol of 2M solution) in THF (40 mL). The solution was warmed to 0 C and then cooled again to -40 C before the addition of iodomethane (10.2 mL, 163.8 mmol). The solution was slowly warmed to room temperature and stirred overnight. The reaction was quenched with an aqueous saturated solution of ammonium chloride and ether was added. The layers were separated and the aqueous layer was washed with ether. The combined organic layers were washed with IN HC1 then dried over MgS04. The product was purified by distillation: XH NMR (400 MHz, MeOD) delta 4.20 - 4.05 (m, 2H), 2.57 - 2.33 (m, 2H), 2.08 - 1.94 (m, 1H), 1.94 - 1.77 (m, 3H), 1.40 (s, 3H), 1.27 (tt, J= 7.1, 1.5 Hz, 3H) ppm.

Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 14924-53-9 ]

Aliphatic Cyclic Hydrocarbons

Chemical Structure| 99769-39-8

[ 99769-39-8 ]

Ethyl 3-methylcyclobutanecarboxylate

Similarity: 1.00

Chemical Structure| 1823373-90-5

[ 1823373-90-5 ]

3-(Ethoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid

Similarity: 0.97

Chemical Structure| 132616-34-3

[ 132616-34-3 ]

Diethyl spiro[3.3]heptane-2,6-dicarboxylate

Similarity: 0.97

Chemical Structure| 28114-90-1

[ 28114-90-1 ]

6-(Ethoxycarbonyl)spiro[3.3]heptane-2-carboxylic acid

Similarity: 0.97

Chemical Structure| 25774-35-0

[ 25774-35-0 ]

Cyclobutanecarboxlic acid anhydride

Similarity: 0.97

Esters

Chemical Structure| 99769-39-8

[ 99769-39-8 ]

Ethyl 3-methylcyclobutanecarboxylate

Similarity: 1.00

Chemical Structure| 1823373-90-5

[ 1823373-90-5 ]

3-(Ethoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid

Similarity: 0.97

Chemical Structure| 132616-34-3

[ 132616-34-3 ]

Diethyl spiro[3.3]heptane-2,6-dicarboxylate

Similarity: 0.97

Chemical Structure| 28114-90-1

[ 28114-90-1 ]

6-(Ethoxycarbonyl)spiro[3.3]heptane-2-carboxylic acid

Similarity: 0.97

Chemical Structure| 28664-03-1

[ 28664-03-1 ]

Ethyl 3-(2-ethoxy-2-oxoethyl)-2,2-dimethylcyclobutanecarboxylate

Similarity: 0.97

; ;