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With triphenylantimony; In dichloromethane; at 20.0℃; for 24.0h;
General procedure: Triphenylstibane(35.5 mg, 0.1 mmol, 10 mol%) and diamine 2 (1.2 mmol) were added to a solution of -hydroxy ketone 1(1 mmol) in toluene (6 mL) under air. The solution was stirred at room temperature and monitored byTLC. The reaction mixture was concentrated under reduced pressure and the residue was purified bycolumn chromatography (CH2Cl2) on silica gel. The products were confirmed by comparison of mp,NMR data, and MS spectra with that in the literature. 822:
6,7-dimethoxy-3-phenylquinoxaline-2-carboxylic acid[ No CAS ]
[ 146535-11-7 ]
Yield
Reaction Conditions
Operation in experiment
70%
for 3.0h;Reflux;
S3. 6,7-Dimethoxy-3-phenylquinoxaline-2-carboxylic acid (Compound 2) under electromagnetic stirringThe reaction was refluxed for 3 h in 30 mL of alcohol.The reflux reaction is heated until the solvent is boiled.After the reaction is completed, the solvent is removed under reduced pressure.Purification by column chromatography gave the title compound 6,7-dimethoxy-2-phenylquinoxaline (AG1296).The yield was 70% and the product purity was 99%.
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