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CAS No. : | 120728-10-1 | MDL No. : | MFCD02682623 |
Formula : | C10H17NO4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ROVVUKFHORPDSM-UHFFFAOYSA-N |
M.W : | 215.25 | Pubchem ID : | 1512646 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | at 0℃; Reflux | Stage 1: Methyl 1-aminocyclobutanecarboxylate Concentrated H2SO4 (10 ml) was added at 0° C. to a solution of 1-(tert-butoxy-carbonylamino)-cyclobutane-1-carboxylic acid (9.29 mmol, 1 equiv.) in MeOH (30 ml), and the reaction was refluxed for 2 hours at 0° C. The solvent was removed under reduced pressure. The residue was taken up in distilled water, adjusted to pH 8-9 with saturated sodium hydrogen carbonate solution and extracted with ethyl acetate (2*200 ml). The combined organic phases were washed with distilled water (2*150 ml) and saturated NaCl solution (2*50 ml) and dried over sodium sulfate. The solvent was concentrated under reduced pressure to yield the desired product in the form of a white solid. Yield: 75percent |
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