[ CAS No. 1194-02-1 ] {[proInfo.proName]}

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Quality Control of [ 1194-02-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1194-02-1 ]

SDS Specification

Alternatived Products of [ 1194-02-1 ]

Product Details of [ 1194-02-1 ]

CAS No. :	1194-02-1	MDL No. :	MFCD00001812
Formula :	C₇H₄FN	Boiling Point :	-
Linear Structure Formula :	C₆H₄(CN)F	InChI Key :	AEKVBBNGWBBYLL-UHFFFAOYSA-N
M.W :	121.11	Pubchem ID :	14517
Synonyms :

Calculated chemistry of [ 1194-02-1 ] Expand+

Physicochemical Properties

Num. heavy atoms :	9
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	31.12
TPSA :	23.79 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.66 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.63
Log Po/w (XLOGP3) :	1.94
Log Po/w (WLOGP) :	2.12
Log Po/w (MLOGP) :	1.88
Log Po/w (SILICOS-IT) :	2.24
Consensus Log Po/w :	1.96

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.31
Solubility :	0.598 mg/ml ; 0.00494 mol/l
Class :	Soluble
Log S (Ali) :	-2.06
Solubility :	1.05 mg/ml ; 0.00863 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.71
Solubility :	0.234 mg/ml ; 0.00193 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.4

Safety of [ 1194-02-1 ]

Signal Word:	Danger	Class:	4.1
Precautionary Statements:	P210-P240-P241-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501	UN#:	1325
Hazard Statements:	H228-H302+H312+H332-H315-H319	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 1194-02-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1194-02-1 ]
Downstream synthetic route of [ 1194-02-1 ]

[ 1194-02-1 ] Synthesis Path-Upstream 1~1

1
[ 1194-02-1 ]
[ 368870-03-5 ]

Reference： [1] Patent: US9301951, 2016, B2,
[2] Patent: WO2017/87837, 2017, A1,

[ 1194-02-1 ] Synthesis Path-Downstream 1~10

1
[ 1194-02-1 ]
[ 456-14-4 ]

Yield	Reaction Conditions	Operation in experiment
35.5%	With ammonia; In diethyl ether; ethanol;	EXAMPLE 40 4-Fluorobenzamidine Hydrochloride 4-Fluorobenzonitrile (10 g, 83 mmol) is dissolved in a mixture of anhydrous ethanol (5 mL) and diethyl ether (70 mL). The reaction mixture is cooled to ice-bath temperature and saturated with gaseous hydrogen chloride for 90 minutes. The mixture is allowed to warm to ambient temperature and stirred overnight. The colorless precipitates are filtered off, washed with diethyl ether and dissolved in anhydrous ethanol (20 mL). Diethyl ether (100 mL) saturated with gaseous ammonia is added and the solution is stirred for 3 hours. The resulting suspension is filtered and the solvent of the filtrate is removed in vacuo. The residue is washed with diisopropyl ether. After drying colourless crystals (5.15 g, 35.5percent) of melting point 210° C. are obtained.
2.9 g (100%)		EXAMPLE 4A 4-Fluorobenzenecarboximidamide Hydrochloride In analogy to the procedure for Example 3A, 2,0 g (16,5 mmol) 4-fluorobenzonitrile and proportionate amounts of the other reagents are used. Yield: 2.9 g (100percent) 1H-NMR (DMSO-d6, 200 MHz): delta=7,5 (m, 2H), 8,0 (m, 2H) ppm.

Reference： [1]Magnetic Resonance in Chemistry,1987,vol. 25,p. 923 - 927
[2]Patent: US5849758,1998,A
[3]Journal of Medicinal Chemistry,1990,vol. 33,p. 1230 - 1241
[4]Patent: US2003/139415,2003,A1
[5]Tetrahedron,2014,vol. 70,p. 1635 - 1645

2
[ 1194-02-1 ]
[ 68-12-2 ]
[ 146137-79-3 ]

Yield	Reaction Conditions	Operation in experiment
39 g		A 1 L four-necked flask was fitted with a constant pressure dropping funnel and mechanical agitation.N2 is replaced three times, and N2 is protected by flow. Turn on mechanical agitation,Add 400 ml of THF and 182 ml of LDA (2 mol/L);40 g of p-fluorobenzonitrile (formula IV, 0.33 mol) was dissolved in 200 ml of THF.Transfer to a constant pressure dropping funnel and start to cool down.Temperature control at -75 ° C ~ -85 ° C dropwise addition of p-fluorobenzonitrile in THF solution; after the end of the addition,The temperature is controlled at -75 ° C ~ -85 ° C for 1 h,At the same time, 26.6 g of DMF was diluted with 30 ml of THF and transferred to a constant pressure dropping funnel. Temperature control at -75 ° C ~ -85 ° C dropwise addition of DMF in THF solution, after the end of the addition,The temperature control was stirred at -75 ° C ~ -85 ° C for 1 h until the reaction with p-fluorobenzonitrile was complete.After the reaction was completed, it was quickly added to 64 ml of acetic acid and quenched, and 400 g of water was added.The layers were separated and the aqueous extracted with EtOAc EtOAc. The organic phase was combined, washed with 400 ml of diluted HCl (1 mol/L), and the organic layer was washed with 400 ml of brine, and the organic39 g of the compound of formula III are obtained as a bright yellow solid

Reference： [1]Tetrahedron Letters,1992,vol. 33,p. 7499 - 7502
[2]Bioorganic and Medicinal Chemistry Letters,2003,vol. 13,p. 561 - 566
[3]Patent: CN108976150,2018,A .Location in patent: Paragraph 0008; 0009

3
[ 1194-02-1 ]
[ 146137-79-3 ]

Yield	Reaction Conditions	Operation in experiment
79%	With n-butyllithium; acetic acid; diisopropylamine; In tetrahydrofuran; N-methyl-acetamide; hexane; water;	EXAMPLE 112 2-Fluoro-5-cyano-benzaldehyde To a stirred, cooled solution (0° C.) of diisopropylamine (15.4 mL, 0.11 mol) in anhydrous tetrahydrofuran (200 mL) n-butyllithium (40 mL of 2.5M in hexane, 0.11 mol) was added from a dropping funnel over a period of 30 min. under argon. The mixture was stirred at that temperature for 30 min. and then cooled to -78° C. A solution of 4-fluoro-benzonitrile (12.1g, 0.1 mol) in dry THF (50 mL) was then added dropwise over 15 min. via syringe and stirred for 1 hour at -78° C. Dimethylformamide (8 mL) was added dropwise from a syringe and the stirring was continued for another 20 min. The reaction was quenched by the rapid addition of acetic acid (20 mL) followed by water (500 mL) and the product was extracted with diethyl ether (2*500 mL). The combined organic layers were washed with 1N HCl, water, saturated sodium chloride and then dried over anhydrous magnesium sulfate, and evaporated to give 2-fluoro-5-cyano-benzaldehyde (11.8 g, 79percent yield) as a light yellow solid. 1H NMR (CDCl3): delta10.32 (s, 1H), 8.18 (dd, 1H, J=6.5, 2.5 Hz), 7.88 (m, 1H), 7.33 (t, 1H, J=9.5 Hz).
74.6%	With acetic acid; diisopropylamine;SiO2; In N-methyl-acetamide; ethyl acetate;	A. 4-Fluoro-3-Formylbenzenecarbonitrile Lithium diisopropyi amide (LDA) (22 mL, 49.56 mmol, 2.0 N commercial solution in heptanes) was added to tetrahydrofliran (50 mL), cooled to 78° C. and under nitrogen. 4-Fluorobenzonitrile was weighed out (5.0 g, 41.3 imnol), placed under nitrogen and dissolved in 25 mL of dry tetrahydrofliran. This solution was added dropwise to the solution of LDA. The resulting solution was stirred at -78° C. for one hour before quenching with 4 mL of dimethylformamide. The temperature was maintained for 10 min before adding 8 mL of acetic acid and 20 mL of distilled water. The crude product was extracted with ethyl acetate. Purification by column chromatography (SiO2, 20percent ethyl acetate in hexanes) afforded 4.6 g of pure product as a white solid (74.6percent yield). -A second batch of the title compound (3.5 g, 56.8 percent/yield) was prepared 20 using 5 g of benzonitrile (41.3 mmol): 1H NMR (CDCl3) delta 10.3 (s, 1H), 8.21 (dd, 1H), 7.91 (d of q, 1H), 7.35 (t, 1H); ES-MS M+was not detected.
	With acetic acid; diisopropylamine; lithium diisopropyl amide;SiO2; In tetrahydrofuran; N-methyl-acetamide; ethyl acetate;	A. 4-Fluoro-3-formylbenzenecarbonitrile Lithium diisopropyl amide (LDA) (22 mL, 49.56 mmol, 2.0 N commercial solution in heptanes) was added to tetrahydrofuran (50 mL), cooled to 78° C. and under nitrogen. 4-Fluorobenzonitrile was weighed out (5.0 g, 41.3 mmol), placed under nitrogen and dissolved in 25 mL of dry tetrahydrofuran. This solution was added dropwise to the solution of LDA. The resulting solution was stirred at -78° C. for one hour before quenching with 4 mL of dimethylformamide. The temperature was maintained for 10 min before adding 8 mL of acetic acid and 20 mL of distilled water. The crude product was extracted with ethyl acetate. Purification by column chromatography (SiO2, 20percent ethyl acetate in hexanes) afforded 4.6 g of pure product as a white solid (74.6percent yield). A second batch of the title compound (3.5 g, 56.8percent yield) was prepared 20 using 5 g of benzonitrile (41.3 mmol): 1H NMR (CDCl3) delta 10.3 (s, 1H), 8.21 (dd, 1H), 7.91 (d of q, 1H), 7.35 (t, 1H); ES-MS M+ was not detected.

With acetic acid; diisopropylamine; lithium diisopropyl amide;SiO2; In tetrahydrofuran; N-methyl-acetamide; ethyl acetate;

A. 4-Fluoro-3-formylbenzenecarbonitrile Lithium diisopropyl amide (LDA) (22 mL, 49.56 mmol, 2.0 N commercial solution in heptanes) was added to tetrahydrofuran (50 mL), cooled to 78° C. and under nitrogen. 4-Fluorobenzonitrile was weighed out (5.0 g, 41.3 mmol), placed under nitrogen and dissolved in 25 mL of dry tetrahydrofuran. This solution was added dropwise to the solution of LDA. The resulting solution was stirred at -78° C. for one hour before quenching with 4 mL of dimethylformamide. The temperature was maintained for 10 min before adding 8 mL of acetic acid and 20 mL of distilled water. The crude product was extracted with ethyl acetate. Purification by column chromatography (SiO2, 20percent ethyl acetate in hexanes) afforded 4.6 g of pure product as a white solid (74.6percent yield). A second batch of the title compound (3.5 g, 56.8percent yield) was prepared 20 using 5 g of benzonitrile (41.3 mmol): 1H NMR (CDCl3) delta 10.3 (s, 1H), 8.21 (dd, 1H), 7.91 (d of q, 1H), 7.35 (t, 1H); ES-MS M+was not detected.

Reference： [1]Patent: US6221914,2001,B1
[2]Patent: US2002/103229,2002,A1
[3]Patent: US2004/127536,2004,A1
[4]Patent: US2005/9876,2005,A1

4
[ 1194-02-1 ]
[ 61439-59-6 ]
4-[(4-Benzyloxyphenyl)ethoxy]benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran;	B. 4-[(4-Benzyloxyphenyl)ethoxy]benzonitrile To a suspension of sodium hydride (60percent, 2.2 g, 55 mmol) in dry tetrahydrofuran (250 ml) was added a solution of 1-benzyl-oxy-4-(2-hydroxyethyl)benzene (11.4 g, 50 mmol) in tetrahydrofuran (50 ml). The reaction was heated to 40° C. for 1 hour. 4-Fluorobenzonitrile (6.7 g, 55 mmol) was added and the mixture was heated to reflux for 5 hours, cooled and neutralized with concentrated HCl. The precipitate was filtered, the filtrate was concentrated to dryness and the resulting solid was recrystallized from ethanol (12 g).

Reference： [1]Patent: US5232945,1993,A

5
[ 1194-02-1 ]
[ 117902-15-5 ]
[ 935254-92-5 ]

Yield	Reaction Conditions	Operation in experiment
70%		EXAMPLE 7; 8-fluoro-7-methoxydibenzo[b,d]furan-2-carbonitrile; A. 4-(4-fluoro-3-methoxyphenoxy)benzonitrile; This compound was prepared according to the method of Sawyer, et al. (Sawyer, J. Scott; Schmittling, Elisabeth A.; Palkowitz, Jayne A.; Smith, William J., III. Journal of Organic Chemistry (1998), 63(18), 6338-6343) from <strong>[117902-15-5]4-fluoro-3-methoxyphenol</strong> (Belanger, Patrice C.; Lau, C. K.; Williams, Haydn W. R.; Dufresne, C.; Scheigetz, John. Canadian Journal of Chemistry (1988), 66(6), 1479-82) (9.71 g, 68.3 mmol) and 4-fluorobenzonitrile (8.27 g, 68.3 mmol), which provided 4-(4-fluoro-3-methoxyphenoxy)benzonitrile (11.69 g, 70percent) as an orange oil.

Reference： [1]Patent: US2007/93548,2007,A1 .Location in patent: Page/Page column 8

6
[ 827-99-6 ]
[ 1194-02-1 ]
[ 1258834-98-8 ]

Yield	Reaction Conditions	Operation in experiment
100%	With sodium carbonate; In N,N-dimethyl-formamide; for 24h;Reflux;	General procedure: A suitable phenol or alcohol (1Meq.), 4-fluorobenzonitrile (1Meq.) and Na2CO3 (2Meq.) were suspended in DMF (3.5mL/mmol) and heated. The reaction was followed by TLC, hexane:diethyl ether (9:1), and after completion (approximately 24h), the desired product extracted with CH2Cl2 (3×50mL). The crude product was purified by flash chromatography, using hexane:diethyl ether (100:1) as eluent.
80%	With caesium carbonate; In N,N-dimethyl-formamide; for 24h;Reflux;	General procedure: A DMF (40 mL) solution containing 4-fluorobenzonitrile (10) (1.0 equiv), m-substituted phenol (11?15) (1.1 equiv), and K2CO3or Cs2CO3(1.0 equiv) was stirred at reflux (24 h). The mixture was cooled, and then H2O (400 mL) was added and the reaction mixture extracted with CH2Cl2(3 x 100 mL). The organic layers were combined, washed with brine (3 x 100 mL), dried (Na2SO4), and evaporated under reduced pressure. The residue was purified by column chromatography using SiO2and 1:30 EtOAc and hexanes as the eluent giving the desired product as a colorless oil.
	With caesium carbonate; In N,N-dimethyl-formamide; at 100℃; for 4h;	726 mg of 4-fluorobenzonitrile, 890 mg of <strong>[827-99-6]3-trifluoromethoxyphenol</strong>, and 1.95 g of cesium carbonate were added to 6 ml of DMF. The obtained mixture was stirred at 100°C for 4 hours. Thereafter, diluted hydrochloric acid was added to the reaction mixture, and it was then extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and it was then dried over magnesium sulfate. The resultant was concentrated by centrifugation under reduced pressure. Sodium hydroxide was added to the residue, and the mixture was then extracted with MTBE. The organic layer was washed with water. The resultant was dried over sodium sulfate, and it was then concentrated by centrifugation under reduced pressure, so as to obtain 1.32 g of 4-(3-trifluoromethoxyphenoxy)benzonitrile.

Reference： [1]European Journal of Medicinal Chemistry,2013,vol. 69,p. 872 - 880
[2]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 3655 - 3666
[3]Patent: EP2248423,2010,A1 .Location in patent: Page/Page column 237-238

7
[ 1194-02-1 ]
[ 35344-95-7 ]
[ 1152958-56-9 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 60℃; for 6h;Inert atmosphere;	To a mixture of 4-fluorobenzonitrile (2.49 g, 20.6 mmol) and 4-formylpyrazole (1.98 g, 20.6 mmo) in 50 mL of DMF at 0 0C was added 95percent sodium hydride (0.54 g, 22.7 mmol) under nitrogen. The mixture was heated to 60 0C for 6 hours and cooled to room temperature, Water was added carefully and the mixture was then extracted with ethyl acetate. The combined extracts were washed with water and brine, and then dried over sodium sulfate, filtered, and concentrated in vacuo to provide crude 4~(4-formyMH-pyrazol-l-yl)benzonitrile.

Reference： [1]Patent: WO2010/19391,2010,A1 .Location in patent: Page/Page column 42-43

8
[ 1194-02-1 ]
[ 824-79-3 ]
[ 530-46-1 ]

Reference： [1]Chemistry - A European Journal,2011,vol. 17,p. 7996 - 7999

9
[ 1194-02-1 ]
[ 10482-56-1 ]
1-cyano-4-[1-methyl-1-(4-methylcyclohex-3-enyl)ethoxy]benzene [ No CAS ]

Reference： [1]Reactive and functional polymers,2011,vol. 71,p. 480 - 488

10
[ 1194-02-1 ]
[ 539-44-6 ]
[ 530-46-1 ]

Reference： [1]Journal of Organic Chemistry,2017,vol. 82,p. 2211 - 2218

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Isomers

Technical Information

? Alkyl Halide Occurrence ? Benzylic Oxidation ? Birch Reduction ? Blaise Reaction ? Blanc Chloromethylation ? Catalytic Hydrogenation ? Complex Metal Hydride Reductions ? Friedel-Crafts Reaction ? Hydride Reductions ? Hydrogenolysis of Benzyl Ether ? Preparation of Aldehydes and Ketones ? Preparation of Alkylbenzene ? Preparation of Amines ? Reactions of Benzene and Substituted Benzenes ? Ritter Reaction ? Thorpe-Ziegler Reaction ? Vilsmeier-Haack Reaction

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P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 1194-02-1 ] {[proInfo.proName]}

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[ 1194-02-1 ] Synthesis Path-Upstream 1~1

[ 1194-02-1 ] Synthesis Path-Downstream 1~10

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Fluorinated Building Blocks

Aryls

Nitriles

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[ 1194-02-1 ]

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