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Stage #1: With sodium hypochlorite; sodium hydroxide In water; butan-1-ol at 20℃; for 18 h; Stage #2: With hydrogenchloride In 1,4-dioxane; ethyl acetate
In step 2 Manufactured 1-(4-Bromophenyl)cyclobutane-1-carboxamide (8.120 g, 31.952 mmol), sodium hypochlorite (11.00percent solution, 25.101 mL, 44.733 mmol), sodium hydroxide (3.00 M solution in water, 29.822 mL, 89.466 mmol) was dissolved in 1-butanol (50 mL) at room temperature and stirred at the same temperature for 18 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was dissolved in ethyl acetate, and hydrochloric acid (4.00 M solution in 1,4-dioxane, 11.982 mL, 47.928 mmol) was added and stirred. The precipitated solid was filtered, washed with ethyl acetate and dried to give the title compound (3.320 g, 39.6 percent) Was obtained in the form of a white solid.
Reference：
[1] Patent: KR2017/43091, 2017, A, . Location in patent: Paragraph 1332; 1339-11341
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