REVIEW A hypolipidemic drug used with exercise, diet, and weight-loss to control elevated cholesterol, or hypercholesterolemia. Simvastatin acts by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A HMG-CoA reductase, the rate-limiting enzyme of the HMG-CoA reductase pathway, the metabolic pathway responsible for the endogenous production of cholesterol.
REFERENCES
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Chen W, Sammani S, Mitra S, Ma SF, Garcia JG, Jacobson JR (2012). Critical role for integrin-beta4 in the attenuation of murine acute lung injury by simvastatin. Am J Physiol Lung Cell Mol Physiol. 303(4):L279-85. PMID 22683568.
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Piechota-Polanczyk A, Goraca A, Demyanets S, Mittlboeck M, Domenig C, Neumayer C, Wojta J, Nanobachvili J, Huk I, Klinger M (2012). Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB. Eur J Vasc Endovasc Surg. 44(2):133-7. PMID 22694979.
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