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  R879    
Ligustrazine HCl
, 98% (HPLC)
 



IDENTITY
CAS Number:76494-51-4
MDL Number:MFCD01109103
MF:C8H12N2.HCl
MW:172.66
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:90-93°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Inhibitory effect on phosphodiesterase and modulates calcium ion mobility

REVIEW

 Ligustrazine hydrochloride is the salt form of tetramethylpyrazine, a natural product from Rhizoma Chuanxiong containing a pyrazine ring, which has been widely used in China for treatment of heart diseases. Ligustrazine, has an inhibitory effect on phosphodiesterase and modulates calcium ion mobility that is associated with heart disease and the cardioprotective effects.

REFERENCES
[1]Kwan, Chiu Yin; Plant-derived drugs acting on cellular Ca2+ mobilization in vascular smooth muscle: tetramethylpyrazine and tetrandrine. Stem Cells (Miamisburg, OH, United States) (1994), 12(1), 64-7.
[2] Ohta A, Yamada K. Physiological and pharmacological activities of simple alkyl- and arylpyrazines. Yakugaku Zasshi. 1997 Jul;117(7):435-47.
[3] Wang X, Chen X. Study on the effects of tetramethylpyrazine on tumor cells: survey and prospects. Zhongguo Zhong Yao Za Zhi. 2003 Apr;28(4):295-8.
[4] Cheng, Xian-chao; Liu, Xin-yong; Xu, Wen-fang; Recent advances in the structural modification of ligustrazine and cerebro/cardiovascular activity of ligustrazine derivatives. Drugs of the Future (2005), 30(10), 1059-1065.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of December 25, 2024


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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

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CATEGORIES

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